| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2114768 | F | PubChem BioAssay. Late stage assay provider counterscreen from the probe development effort to identify selective inverse agonists of the Retinoic acid receptor-related Orphan Receptor Gamma (RORC): radioligand binding for ROR gamma using Scintillation Proximity Assay (SPA). (Class of assay: confirmatory) | Homo sapiens | 1 | assay format | PubChem BioAssays | ||
| 2. | ALA1961836 | B | Effect on RORG(NR1F3) dependent reporter activity in HEK293 cells at 20 uM | 2 | cell-based format | Scientific Literature | |||
| 3. | ALA2114842 | F | PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) | Homo sapiens | 512 | assay format | PubChem BioAssays | ||
| 4. | ALA2114928 | F | PubChem BioAssay. Dose response orthogonal assay of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a colorimetric intensity assay. (Class of assay: confirmatory) | Homo sapiens | 166 | assay format | PubChem BioAssays | ||
| 5. | ALA1738628 | U | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). (Class of assay: screening) [Related pubchem assays (depositor defined):AID2139, AID2277] Panel member name: RORG | 6 | assay format | PubChem BioAssays | |||
| 6. | ALA2317475 | B | Displacement of [3H]-T0903017 from GST-tagged ROR-gamma (unknown origin) after 20 hrs | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 7. | ALA2317476 | B | Modulation of ROR-gamma Gal4-DBD-NR-LBD (unknown origin) expressed in HEK293T cells assessed as repression of transcriptional activity at 10 uM after 20 hrs by luciferase assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 8. | ALA2317477 | B | Modulation of ROR-gamma Gal4-DBD-NR-LBD (unknown origin) expressed in HEK293T cells assessed as repression of transcriptional activity after 20 hrs by luciferase assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 9. | ALA2327328 | B | Antagonist activity RORgammat in human Th17 cells assessed as inhibition of cell differentiation by measuring IL-17A expression at 0.5 uM after 6 days by flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA2327333 | B | Antagonist activity at transactivation domain of RORgammat (unknown origin) expressed in HEK293t cells co-expressing Gal4-DNA binding domain | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA2327511 | B | Antagonist activity at transactivation domain of RORgammat (unknown origin) expressed in Drosophila Schneider cells co-expressing Gal4-DNA binding domain | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 12. | ALA2327512 | B | Displacement of fluorescein-labeled 25-hydroxycholesterol from human RORgammat LBD (262-518) Escherichia coli BL21(DE3) after 6 hrs by fluorescence polarization assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA3097487 | B | Inverse agonist activity at GAL4-fused human RORc expressed in HEK293T cells assessed as suppression of basal transcriptional activity after 20 hrs by dual-glo luciferase reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA3097488 | B | Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 15. | ALA3097489 | B | Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 16. | ALA3097490 | B | Displacement of [3H2]-25-hydroxycholesterol from N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system after 3 hrs by scintillation counting analysis | Homo sapiens | 29 | assay format | Scientific Literature | ||
| 17. | ALA3106082 | B | Binding affinity to RORgammat receptor ligand binding domain (unknown origin) assessed as change in melting temperature at 50 uM by circular dichroism spectrophotometric analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 18. | ALA3106083 | B | Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 19. | ALA3106086 | B | Inhibition of N-(2-chloro-6-fluorobenzyl)-N-((2'-methoxy-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide-induced APC-labeled RORgammat receptor ligand binding domain (unknown origin) after 1 hr by FRET assay | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 20. | ALA3106087 | B | Inhibition of APC-labeled RORgammat receptor ligand binding domain (unknown origin) after 1 hr by FRET assay | Homo sapiens | 52 | single protein format | Scientific Literature |
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