| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1743327 | A | Substrate of human UDP-glucuronosyltransferase UGT1A6 | Homo sapiens | 8 | ALA1743201 | single protein format | Scientific Literature | |
| 2. | ALA1908083 | A | Specific activity of expressed human recombinant UGT1A6 | Homo sapiens | 122 | ALA1907987 | single protein format | Scientific Literature | |
| 3. | ALA1908117 | B | Drug glucuronidation reaction catalyzed by human recombinant UGT1A6 | Homo sapiens | 4 | ALA1908105 | single protein format | Scientific Literature | |
| 4. | ALA1908127 | B | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A6 | Homo sapiens | 2 | ALA1908105 | single protein format | Scientific Literature | |
| 5. | ALA1908131 | B | Inhibition of AZT glucuronidation by human recombinant UGT1A6 | Homo sapiens | 1 | ALA1908105 | single protein format | Scientific Literature | |
| 6. | ALA2046059 | A | Activity at UGT1A6 in human liver microsomes at 50 uM incubated for 3 mins prior to NADPH-addition measured up to 120 mins by HPLC/UV analysis | Homo sapiens | 1 | ALA2040715 | microsome format | Scientific Literature | |
| 7. | ALA3398974 | A | Drug metabolism assessed as UGT1A6-mediated compound glucuronidation in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 2 | ALA3397011 | assay format | Scientific Literature | |
| 8. | ALA3398979 | A | Activation of UGT1A6 in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 1 | ALA3397011 | assay format | Scientific Literature | |
| 9. | ALA3399065 | A | Inhibition of of UGT1A6 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC method | Homo sapiens | 1 | ALA3397011 | assay format | Scientific Literature | |
| 10. | ALA3541112 | A | Activity of human UGT1A6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 11. | ALA3539909 | A | Drug metabolism assessed as recombinant human UGT1A6 assessed as O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 12. | ALA3539919 | A | Drug metabolism assessed as recombinant human UGT1A6 assessed as N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 13. | ALA3541849 | A | Drug metabolism assessed as UDPGA-fortified human recombinant UGT1A6-mediated DTG glucuronide metabolite ((2S,3S,4S,5R,6S)-6-((4R,12aS)-9-(2,4-difluorobenzylcarbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazin-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid) formation at 16 uM after 120 mins by radio-HPLC analysis | Homo sapiens | 1 | ALA3526034 | single protein format | Scientific Literature | |
| 14. | ALA3538803 | A | Drug metabolism assessed as human UGT1A6-mediated N-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 1 | ALA3525967 | cell-based format | Scientific Literature | |
| 15. | ALA3541445 | A | Activity of human recombinant UGT1A6 expressed in insect cells assessed as enzyme mediated glucuronidation at 500 uM by LC-MS/MS method | Homo sapiens | 1 | ALA3526061 | cell-based format | Scientific Literature | |
| 16. | ALA3541754 | A | Drug metabolism assessed as human UGT1A6-mediated N'-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 1 | ALA3525967 | cell-based format | Scientific Literature | |
| 17. | ALA3534355 | A | Activity of human recombinant UGT1A6 expressed in baculovirus-infected insect cells assessed as enzyme-mediated glucuronidation per mg of protein after 10 mins in presence of UDPGA | Homo sapiens | 1 | ALA3526122 | cell-based format | Scientific Literature | |
| 18. | ALA3531820 | A | Activity of human recombinant UGT1A6 expressed in insect cells assessed as enzyme mediated glucuronidation at 12.5 uM by LC-MS/MS method | Homo sapiens | 1 | ALA3526061 | cell-based format | Scientific Literature | |
| 19. | ALA3531836 | A | Activity of human recombinant UGT1A6 expressed in insect cells assessed as enzyme mediated glucuronidation by LC-MS/MS method | Homo sapiens | 1 | ALA3526061 | cell-based format | Scientific Literature | |
| 20. | ALA3531837 | A | Activity of human recombinant UGT1A6 expressed in insect cells assessed as enzyme mediated glucuronidation per mg protein by LC-MS/MS method | Homo sapiens | 1 | ALA3526061 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!