| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1743329 | A | Substrate of human UDP-glucuronosyltransferase UGT1A8 | Homo sapiens | 12 | ALA1743201 | single protein format | Scientific Literature | |
| 2. | ALA1908085 | A | Specific activity of expressed human recombinant UGT1A8 | Homo sapiens | 111 | ALA1907987 | single protein format | Scientific Literature | |
| 3. | ALA1908119 | B | Drug glucuronidation reaction catalyzed by human recombinant UGT1A8 | Homo sapiens | 7 | ALA1908105 | single protein format | Scientific Literature | |
| 4. | ALA3541115 | A | Activity of human UGT1A8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA | Homo sapiens | 1 | ALA3526048 | assay format | Scientific Literature | |
| 5. | ALA3539911 | A | Drug metabolism assessed as recombinant human UGT1A8 assessed as O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 6. | ALA3539921 | A | Drug metabolism assessed as recombinant human UGT1A8 assessed as N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526000 | single protein format | Scientific Literature | |
| 7. | ALA3537739 | A | Drug metabolism assessed as human recombinant UGT1A8-mediated compound formation treated with AMG 853 at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526017 | single protein format | Scientific Literature | |
| 8. | ALA3537403 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT1A8-mediated 17-epiestriol-3-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | ALA3525985 | single protein format | Scientific Literature | |
| 9. | ALA3537764 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT1A8-mediated estradiol-3-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | ALA3525985 | single protein format | Scientific Literature | |
| 10. | ALA3537765 | A | Drug level assessed as recombinant human C-terminal His-tagged UGT1A8-mediated estradiol-3-glucuronide formation from 200 uM estradiol after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 2 | ALA3525985 | single protein format | Scientific Literature | |
| 11. | ALA3538805 | A | Drug metabolism assessed as human UGT1A8-mediated N-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 1 | ALA3525967 | cell-based format | Scientific Literature | |
| 12. | ALA3541447 | A | Activity of human recombinant UGT1A8 expressed in insect cells assessed as enzyme mediated glucuronidation at 500 uM by LC-MS/MS method | Homo sapiens | 1 | ALA3526061 | cell-based format | Scientific Literature | |
| 13. | ALA3541756 | A | Drug metabolism assessed as human UGT1A8-mediated N'-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis | Homo sapiens | 1 | ALA3525967 | cell-based format | Scientific Literature | |
| 14. | ALA3534350 | A | Activity of human recombinant UGT1A8 expressed in baculovirus-infected insect cells assessed as enzyme-mediated glucuronidation per mg of protein after 10 mins in presence of UDPGA | Homo sapiens | 1 | ALA3526122 | cell-based format | Scientific Literature | |
| 15. | ALA3534363 | A | Activity of human recombinant UGT1A8 expressed in baculovirus-infected insect cells assessed as enzyme-mediated glucuronidation after 10 mins in presence of UDPGA | Homo sapiens | 1 | ALA3526122 | cell-based format | Scientific Literature | |
| 16. | ALA3534364 | A | Inhibition of human recombinant UGT1A8 after 10 mins in presence of UDPGA | Homo sapiens | 1 | ALA3526122 | single protein format | Scientific Literature | |
| 17. | ALA3534365 | A | Activity of human recombinant UGT1A8 expressed in baculovirus-infected insect cells assessed as intrinsic clearance for enzyme-mediated glucuronide formation per mg of protein at 1 to 250 uM after 10 mins in presence of UDPGA | Homo sapiens | 1 | ALA3526122 | cell-based format | Scientific Literature | |
| 18. | ALA3531821 | A | Activity of human recombinant UGT1A8 expressed in insect cells assessed as enzyme mediated glucuronidation at 12.5 uM by LC-MS/MS method | Homo sapiens | 1 | ALA3526061 | cell-based format | Scientific Literature | |
| 19. | ALA3532966 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT1A8-mediated estriol-3-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA | Homo sapiens | 1 | ALA3525985 | single protein format | Scientific Literature | |
| 20. | ALA3532972 | A | Drug metabolism assessed as recombinant human C-terminal His-tagged UGT1A8-mediated 16-epiestriol-3-glucuronide formation after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA | Homo sapiens | 1 | ALA3525985 | single protein format | Scientific Literature |
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