| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2046060 | A | Activity at UGT1A9 in human liver microsomes at 50 uM incubated for 3 mins prior to NADPH-addition measured up to 120 mins by HPLC/UV analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 2. | ALA1908086 | A | Specific activity of expressed human recombinant UGT1A9 | Homo sapiens | 122 | single protein format | Scientific Literature | ||
| 3. | ALA1908120 | B | Drug glucuronidation reaction catalyzed by human recombinant UGT1A9 | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 4. | ALA1908129 | B | Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A9 | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 5. | ALA1908146 | B | Inhibition of propofol (assayed at the Km) glucuronidation by human recombinant UGT1A9 (+/- 15% inhibition at 5mM VPA) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA1743330 | A | Substrate of human UDP-glucuronosyltransferase UGT1A9 | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 7. | ALA3398975 | A | Drug metabolism assessed as UGT1A9-mediated compound glucuronidation in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 8. | ALA3398989 | A | Activation of UGT1A9 in pooled mixed-gender human liver microsomes at 50 uM preincubated at 37 degC for 3 mins before UDPGA addition by HPLC method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA3399066 | A | Inhibition of of UGT1A9 in pooled mixed-gender human liver microsomes using 4-methylumbelliferone substrate by HPLC method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA3537957 | A | Drug metabolism assessed as UGT1A9 activity in human liver microsome assessed as of O-glucuronidation at 25 to 200 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 11. | ALA3537960 | A | Drug metabolism assessed as recombinant human UGT1A9 assessed as O-glucuronidation at 25 to 200 uM incubated for 60 mins by LC-MS/MS analysis in presence of 10 uM hecogenin relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3541113 | A | Activity of human UGT1A9 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA3538590 | A | Drug metabolism in human intestinal microsomes assessed as UGT1A9-mediated unbound intrinsic glucuronidation clearance at 1 uM after 30 to 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA3538592 | A | Drug metabolism in human intestinal microsomes assessed as UGT1A9-mediated unbound intrinsic glucuronidation clearance at 5 uM after 30 to 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3538597 | A | Ratio of UGT1A9-mediated unbound intrinsic glucuronidation clearance in human kidney microsomes to UGT1A9-mediated unbound intrinsic glucuronidation clearance in human liver microsomes at 1 uM | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA3539922 | A | Drug metabolism assessed as recombinant human UGT1A9 assessed as N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3539931 | A | Drug metabolism assessed as recombinant human UGT1A9 assessed as velocity of O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3540231 | A | Drug metabolism assessed as recombinant human UGT1A9 assessed as O-glucuronidation at 10 to 400 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3540232 | A | Drug metabolism assessed as recombinant human UGT1A9 assessed as O-glucuronidation measured per mg of protein at 10 to 400 uM incubated for 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3540233 | A | Intrinsic clearance in recombinant human UGT1A9 measured per mg of protein at 10 to 400 uM by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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