| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1767464 | B | Binding affinity to CBX7 by chemiluminescent assay | 2 | single protein format | Scientific Literature | |||
| 2. | ALA2429075 | B | Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assay | Homo sapiens | 56 | single protein format | Scientific Literature | ||
| 3. | ALA3136680 | B | Inhibition of CBX7 (8 to 62) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H3K9Me3 as substrate incubated for 30 mins at room temperature followed by incubation under dark condition for 30 mins by AlphaScreen assay | Homo sapiens | 25 | assay format | Scientific Literature | ||
| 4. | ALA3222536 | B | Antagonist activity at Flag-tagged CBX7 (unknown origin) assessed as inhibition of CBX7/biotinylated H3K9Me3 peptide interaction after 30 mins by AlphaScreen assay | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 5. | ALA3222537 | B | Antagonist activity at Flag-tagged CBX7 (unknown origin) assessed as inhibition of CBX7/biotinylated H3K9Me3 peptide interaction at 30 uM after 30 mins by AlphaScreen assay | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 6. | ALA3242415 | B | Displacement of FITC-labeled H3K27me3 from CBX7 (unknown origin) after 15 mins by fluorescence polarization assay | Homo sapiens | 60 | single protein format | Scientific Literature | ||
| 7. | ALA3242416 | B | Binding affinity to CBX7 (unknown origin) by isothermal titration calorimetry assay | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 8. | ALA3782540 | B | Binding affinity to N-terminal His6-tagged human CBX7 (8 to 62) expressed in Escherichia coli BL21 using FITC-peptide-3 as competitive binding probe by fluorescence polarization assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 9. | ALA3782547 | B | Binding affinity to N-terminal His6-tagged human CBX7 (8 to 62 residues) expressed in Escherichia coli BL21 by surface plasmon resonance assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA3782548 | B | Binding affinity to human CBX7 V13A mutant expressed in Escherichia coli BL21 by surface plasmon resonance assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 11. | ALA3829385 | B | Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SETDB1-K1170me3/H3K27me3/ANRIL-LoopC RNA by fluorescence anisotropy assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 12. | ALA3829390 | B | Antagonist activity at CBX7ChD (7 to 66 residues) expressed in human PC3 cells assessed as transcriptional derepression of p16INK4a at 50 to 250 uM after 12 hrs by qPCR method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA3829391 | B | Binding affinity to 15N-labeled CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells by HSQC/NMR titration | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3829401 | B | Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as compound/protein/FITC-labeled loop C of ANRIL ternary complex formation by fluorescence anisotropy assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA3829402 | B | Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as enhancement of FITC-ANRIL-loopC/FITC-16mer-RNA binding to protein at 25 to 250 uM by fluorescence anisotropy assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3829403 | B | Antagonist activity at CBX7ChD (7 to 66 residues) expressed in human PC3 cells assessed as transcriptional derepression of p16INK4a after 12 hrs by qPCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3829409 | B | Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as enhancement of FITC-ANRIL-loopC/FITC-16mer-RNA binding to protein by fluorescence anisotropy assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3858693 | B | Binding affinity to recombinant human C-terminal His-tagged CBX7 chromodomain (8 to 62 residues) expressed in Escherichia coli Rosetta BL21(DE3)pLysS by SPR method | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 19. | ALA3858697 | B | Antagonist activity at recombinant human C-terminal His-tagged CBX7 chromodomain (8 to 62 residues) expressed in Escherichia coli Rosetta BL21(DE3)pLysS using biotin-labeled H3K9me3 measured after 30 mins by AlphaScreen assay | Homo sapiens | 47 | assay format | Scientific Literature | ||
| 20. | ALA3858721 | B | Binding affinity to human C-terminal His-tagged CBX7 chromodomain (8 to 62 residues) expressed in Escherichia coli Rosetta BL21(DE3)pLysS by ITC method | Homo sapiens | 2 | assay format | Scientific Literature |
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