# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1794547 | F | PUBCHEM_BIOASSAY: SAR Analysis for the identification of selective inhibitors of the transient receptor potential cation channel C4 (TRPC4) in TRPC6 expressing cells: MPD Assay CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2247, AID2256, AID2601] | 16 | cell-based format | PubChem BioAssays | |||
2. | ALA4015182 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as increase in intracellular calcium level measured for 2.5 mins by Fluo-8-AM dye-based fluorescence assay | Mus musculus | 16 | cell-based format | Scientific Literature | ||
3. | ALA4015193 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as peak current changes at +80 mV by whole cell patch-clamp method | Mus musculus | 4 | cell-based format | Scientific Literature | ||
4. | ALA4015206 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as induction of membrane potential depolarization measured for 2.5 mins by FLIPR assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA4015209 | B | Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as increase in intracellular calcium level by Fluo-4-AM dye-based fluorescence assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
6. | ALA4015211 | B | Antagonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as channel desensitization at 20 to 100 uM at +80 mV in presence of 0.1 mM Ca2+ by whole cell patch-clamp method | Mus musculus | 4 | cell-based format | Scientific Literature | ||
7. | ALA4122838 | B | Inhibition of mouse TRPC6 | Mus musculus | 1 | single protein format | Scientific Literature | ||
8. | ALA4255378 | B | Inhibition of mouse TRPC6 expressed in HEK293 cells assessed as reduction in M085-induced intracellular calcium flux pretreated for 5 mins followed by M085 addition measured after 300 secs by Fluo-8AM dye based FLIPR assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
9. | ALA4377052 | B | Inhibition of HA-tagged mouse TRPC6 expressed in HEK293 cells assessed as reduction in acetylcholine-induced membrane potential by FLIPR membrane potential dye based assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
10. | ALA4377057 | B | Inhibition of mouse TRPC6 expressed in HEK293 cells co-expressing M5 receptor assessed as reduction in carbachol-induced membrane potential by FMP-2 dye based assay | Mus musculus | 7 | cell-based format | Scientific Literature | ||
11. | ALA4714760 | B | Inhibition of mouse TRPC6 expressed in HEK293 cells assessed as inhibition of GSK170-induced current at 10 uM by whole cell patch-clamp method | Mus musculus | 1 | cell-based format | Scientific Literature |