# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1806125 | F | Agonist activity at TrkB in E17 rat primary rat cortical neurons assessed as AKT phosphorylation at Ser 473 after 15 mins by titration assay | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
2. | ALA1806126 | F | Agonist activity at TrkB in E17 rat primary rat cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
3. | ALA1806127 | F | Agonist activity at TrkB in E17 rat primary rat cortical neurons assessed as AKT phosphorylation at Ser 473 at 10 to 50 nM after 15 mins by titration assay | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
4. | ALA1806128 | F | Agonist activity at TrkB in E17 rat primary rat cortical neurons assessed as AKT phosphorylation at Ser 473 at 100 nM after 15 mins by titration assay | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
5. | ALA1806129 | F | Agonist activity at TrkB in E17 rat primary cortical neurons at 500 nM after 5 mins by immunoblotting | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
6. | ALA1806130 | F | Agonist activity at TrkB in E17 rat primary cortical neurons at 500 nM after 10 mins by immunoblotting | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
7. | ALA1806131 | F | Agonist activity at TrkB in E17 rat primary cortical neurons at 500 nM after 30 to 180 mins by immunoblotting | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
8. | ALA1806132 | F | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at S473 at 500 nM after 1 to 16 hrs by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
9. | ALA1806133 | F | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as MAPK phosphorylation at 500 nM after 1 to 16 hrs by ELISA | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
10. | ALA1806139 | F | Agonist activity at TrkB in E17 rat primary cortical neurons by immunoblotting | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
11. | ALA1806140 | F | Agonist activity at TrkB in E16 rat embryonic cortical neurons assessed as inhibition of glutamate-induced caspase 3 activation at 10 nM after 30 mins followed by 16 hrs of 50 uM glutamate-challenge by ELISA | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
12. | ALA1806142 | F | Agonist activity at TrkB in E16 rat embryonic cortical neurons assessed as inhibition of glutamate-induced caspase 3 activation at 50 to 500 nM after 30 mins followed by 16 hrs of 50 uM glutamate-challenge by ELISA | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
13. | ALA1806227 | F | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as TrkB phosphorylation at 817 at 500 nM after 15 mins by immunoblotting | Rattus norvegicus | 10 | cell-based format | Scientific Literature | ||
14. | ALA1806228 | B | Inhibition of TrkB activation in E17 rat primary cortical neurons at 500 nM after 15 mins by immunoblotting | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
15. | ALA1806229 | F | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA relative to control | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
16. | ALA1806231 | F | Agonist activity at TrkB in E17 rat primary rat cortical neurons assessed as AKT phosphorylation at Ser 473 at 10 nM after 15 mins by titration assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
17. | ALA1806233 | F | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA | Rattus norvegicus | 41 | cell-based format | Scientific Literature | ||
18. | ALA1935922 | F | Agonist activity at TrkB in E18 Sprague-Dawley rat hippocampal neurons assessed as induction of TrkB autophosphorylation at Tyr490 at 100 uM after 1 hr by Western blotting analysis | Rattus norvegicus | 14 | tissue-based format | Scientific Literature | ||
19. | ALA1935923 | F | Antagonist activity at TrkB in E18 Sprague-Dawley rat hippocampal neurons assessed as inhibition of BDNF-induced TrkB phosphorylation at Tyr490 at 100 uM preincubated for 1 hr followed by BDNF induction for 10 mins by Western blotting analysis | Rattus norvegicus | 10 | tissue-based format | Scientific Literature | ||
20. | ALA2214416 | F | Agonist activity at TrkB receptor in rat primary neurons assessed as Akt phosphorylation at 500 nM after 15 mins by immunoblotting analysis | Rattus norvegicus | 2 | assay format | Scientific Literature |