| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1803252 | B | Inhibition of Cdc37 interaction with heme-regulated [35S]His-tagged eIF2alpha K199R mutant kinase in reticulocyte lysate assessed as coadsorbed Cdc37 at 80 uM after 40 mins by SDS-PAGE and Western blot analysis | 1 | assay format | Scientific Literature | |||
| 2. | ALA1803255 | B | Inhibition of Cdc37 interaction with [35S]His-tagged HRI K199R mutant in reticulocyte lysate assessed as coadsorbed Cdc37 at 20 mM after 40 mins by SDS-PAGE and Western blot analysis | 1 | assay format | Scientific Literature | |||
| 3. | ALA1803258 | B | Inhibition of Cdc37 interaction with [35S]His-tagged HRI K199R mutant in reticulocyte lysate assessed as coadsorbed Cdc37 at 100 uM after 40 mins by SDS-PAGE and Western blot analysis | 1 | assay format | Scientific Literature | |||
| 4. | ALA1803261 | B | Inhibition of Cdc37 interaction with [35S]His-tagged HRI K199R mutant in reticulocyte lysate assessed as coadsorbed Cdc37 at 4 mM after 40 mins by SDS-PAGE and Western blot analysis | 1 | assay format | Scientific Literature | |||
| 5. | ALA1803503 | B | Inhibition of Cdc37 interaction with [35S]His-tagged HRI K199R mutant in reticulocyte lysate assessed as coadsorbed Cdc37 at 400 uM after 40 mins by SDS-PAGE and Western blot analysis | 1 | assay format | Scientific Literature | |||
| 6. | ALA1803506 | B | Inhibition of Cdc37 interaction with [35S]His-tagged HRI K199R mutant in reticulocyte lysate assessed as coadsorbed Cdc37 at 50 uM after 40 mins by SDS-PAGE and Western blot analysis | 1 | assay format | Scientific Literature | |||
| 7. | ALA4379713 | B | Inhibition of Cdc37 in human A549 cells assessed as disruption of HSP90 alpha-Cdc37 interaction by measuring decrease in Cdc37 protein level at 5 uM incubated for 6 hrs by immunoprecipitation based immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4379714 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring decrease in Akt phosphorylation level at 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4379715 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring decrease in CDK4 protein level at 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4379716 | B | Binding affinity to recombinant Cdc37 (unknown origin) assessed as inhibition of biotin labeled 3-[3-cyano-3-(4-fluorophenyl)prop-2-enoyl]oxypropyl(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylate binding to enzyme at 0.25 to 0.5 uM incubated with compound for 2 hrs before or after incubation with biotin labeled 3-[3-cyano-3-(4-fluorophenyl)prop-2-enoyl]oxypropyl(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylate for 2 hrs by pull down assay based immunoblot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4379719 | B | Binding affinity to full length CDC37 (unknown origin) assessed as reduction in absorption at 440 nm reaching equilibrium within 15 mins at 100 uM by UV absorption analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4379721 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring decrease in Akt phosphorylation level incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4379722 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring decrease in CDK4 protein level incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4379723 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring increase in BAX protein level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4379724 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring increase in cleaved caspase-3 protein level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4379725 | B | Binding affinity to Cdc37 in human A549 cells assessed as inhibition of HSP90-Cdc37 interaction by measuring decrease in Bcl2 protein level at 1.25 to 5 uM incubated for 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5132807 | B | Inhibition of CDC37 in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA5160506 | B | Binding affinity to Cdc37 (unknown origin) at 80 uM by UV-Vis spectrophotometric analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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