| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1814966 | B | Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay | 18 | single protein format | Scientific Literature | |||
| 2. | ALA1814967 | B | Inhibition of PARG using [alpha-32P]ADP-ribose polymers up to 500 uM after 5 mins by TRAP assay | 4 | single protein format | Scientific Literature | |||
| 3. | ALA1814972 | B | Inhibition of PARG in human SCC25 cells assessed as inhibition of MNNG-induced poly(ADP-ribose) formation at 1 mM after 20 mins by chemiluminescent ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA1814973 | B | Inhibition of PARG in human SCC25 cells assessed as inhibition of MNNG-induced poly(ADP-ribose) formation at 1 mM after 20 mins by chemiluminescent ELISA in presence of benzamide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA1814974 | B | Inhibition of PARG in human SCC25 cells assessed as increase of MNNG-induced poly(ADP-ribose) formation at 1 mM after 10 mins by chemiluminescent ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA1815006 | B | Inhibition of PARG in human SCC25 cells assessed as increase of MNNG-induced poly(ADP-ribose) formation at 1 mM up to 80 mins by chemiluminescent ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA1815007 | B | Inhibition of PARG using [alpha-32P]ADP-ribose polymers at 500 uM after 5 mins by TRAP assay | 8 | single protein format | Scientific Literature | |||
| 8. | ALA4265322 | B | Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assay | Homo sapiens | 118 | single protein format | Scientific Literature | ||
| 9. | ALA4265323 | B | Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured after 1 hr by Alexofluor 488-conjugated secondary antibody and Hoechst 33342 staining based assay | Homo sapiens | 50 | cell-based format | Scientific Literature | ||
| 10. | ALA4333011 | B | Inhibition of recombinant full-length human C-terminal His6-tagged PARG (1 to 976 residues) expressed in Escherichia coli BL21 (DE3) cells using 6HIS-TEV-PARylated-PARP1 (2 to 1014 residues) as substrate measured after 10 mins by HTRF assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 11. | ALA4333012 | B | Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured after 30 to 120 mins by Alexafluor 488-conjugated secondary antibody and Hoechst 33342 staining based assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 12. | ALA4617152 | B | Inhibition of recombinant human PARG assessed as mono(ADP-R) release using PAR as substrate measured after 15 mins by HPLC analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 13. | ALA5105270 | B | Binding affinity to human PARG assessed as dissociation constant by SPR analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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