| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1827133 | B | Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 20 hrs by luciferase reporter gene assay | 27 | ALA1821692 | cell-based format | Scientific Literature | ||
| 2. | ALA1827134 | B | Inhibition of SREBP2 activation expressed in CHO-K1 cells assessed as decrease in mature form of SREBP at 1 to 20 uM after 6 hrs by Western blot analysis | 1 | ALA1821692 | cell-based format | Scientific Literature | ||
| 3. | ALA1827135 | B | Inhibition of SREBP2 activation expressed in CHO-K1 cells by densitometric analysis | 2 | ALA1821692 | cell-based format | Scientific Literature | ||
| 4. | ALA1827136 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of MVK gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 5. | ALA1827137 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of HMG-CoA reductase gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 6. | ALA1827138 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of ATP citrate lyase gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 7. | ALA1827139 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of INSIG1 gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 8. | ALA1827140 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of HMG-CoA synthase 1 gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 9. | ALA1827141 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of isopentenyl diphosphate delta isomerase 1 gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 10. | ALA1827142 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of stearoyl-CoA desaturase gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 11. | ALA1827143 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of LDLR gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 12. | ALA1827144 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of RPL13A gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 13. | ALA1827354 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of B2M gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 14. | ALA1827355 | B | Inhibition of SREBP2 activation in human DU145 cells assessed as down-regulation of GAPDH gene by quantitative RT-PCR analysis | Homo sapiens | 1 | ALA1821692 | cell-based format | Scientific Literature | |
| 15. | ALA3788713 | B | Induction of SREBP2 maturation in human HepG2 cells at 10 uM after overnight incubation by immunoblot analysis | Homo sapiens | 1 | ALA3785029 | cell-based format | Scientific Literature | |
| 16. | ALA3788714 | B | Inhibition of SREBP2 maturation in human HepG2 cells at 25 uM after overnight incubation by immunoblot analysis in the presence of atorvastatin | Homo sapiens | 1 | ALA3785029 | cell-based format | Scientific Literature | |
| 17. | ALA3788715 | B | Inhibition of SREBP2 in human HepG2 cells assessed as downregulation of PCSK9 mRNA expression by RT-PCR analysis | Homo sapiens | 1 | ALA3785029 | cell-based format | Scientific Literature | |
| 18. | ALA3788716 | B | Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion at 50 uM after 16 hrs by ELISA | Homo sapiens | 1 | ALA3785029 | cell-based format | Scientific Literature | |
| 19. | ALA3788717 | B | Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion at 10 uM after 16 hrs by ELISA | Homo sapiens | 1 | ALA3785029 | cell-based format | Scientific Literature | |
| 20. | ALA3788940 | B | Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion after 16 hrs by ELISA | Homo sapiens | 1 | ALA3785029 | cell-based format | Scientific Literature |
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