| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1827810 | B | Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrs | Mus musculus | 27 | cell-based format | Scientific Literature | ||
| 2. | ALA2150432 | B | Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of TNFalpha production after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA2150433 | B | Inhibition of TLR4 in LPS-stimulated mouse BV2 cells assessed as reduction of NF-kappaB activation after 24 hrs by Dual-GLO luciferase assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA2150434 | B | Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of NO production after 24 hrs | Mus musculus | 24 | cell-based format | Scientific Literature | ||
| 5. | ALA2150436 | B | Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of IL1-beta production after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA2150437 | B | Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of TNFalpha production at 3 to 10 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA2150438 | B | Inhibition of TLR4 in LPS-stimulated mouse BV2 cells assessed as reduction of NF-kappaB activation up to 10 uM after 24 hrs by Dual-GLO luciferase assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA2150439 | B | Inhibition of TLR4 in LPS-stimulated mouse RAW264.7 cells assessed as reduction of IL1-beta production at 3 to 10 uM after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA1226057 | B | Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells at 200 nM to 200 uM | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA1226059 | B | Inhibition TLR4-mediated NO production in mouse RAW264.7 cells at 300 uM | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA1913431 | F | Agonist activity at TLR4 in thioglycollate-elicited mouse peritoneal macrophages assessed as induction of IL-6 production in after 18 hrs by ELISA | Mus musculus | 8 | assay format | Scientific Literature | ||
| 12. | ALA1913432 | B | Inhibition of LPS-induced TLR4 activation in thioglycollate-elicited mouse peritoneal macrophages assessed as inhibition of IL-6 production after 18 hrs by ELISA | Mus musculus | 7 | single protein format | Scientific Literature | ||
| 13. | ALA1913434 | B | Enhancement of LPS-induced TLR4 activation in mouse peritoneal macrophages assessed as IL-6 production at 0.6 to 19.2 uM after 18 hrs by ELISA | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 14. | ALA2389978 | B | Activation of mouse TLR4 transfected in HEK293 cells after 18 hrs by SEAP assay relative to N-cyclohexyl-2-(4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-ylthio)acetamide | Mus musculus | 42 | cell-based format | Scientific Literature | ||
| 15. | ALA2389980 | B | Activation of TLR4 in C57BL/6 mouse BMDC cells assessed as AUC of IP10 release at 5 uM after 18 hrs by ELISA relative to N-cyclohexyl-2-(4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-ylthio)acetamide | Mus musculus | 42 | cell-based format | Scientific Literature | ||
| 16. | ALA2389981 | B | Activation of TLR4 in C57BL/6 mouse BMDC cells assessed as AUC of IL6 release after 18 hrs by ELISA relative to N-cyclohexyl-2-(4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-ylthio)acetamide | Mus musculus | 42 | cell-based format | Scientific Literature | ||
| 17. | ALA2389982 | B | Activation of TLR4-mediated type 1 IFN release in C57BL/6 mouse BMDC cells after overnight incubation by luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2389983 | B | Activation of TLR4-mediated type 1 IFN release in C57BL/6 mouse BMDC cells assessed as IP10 level after overnight incubation by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA2389986 | B | Activation of mouse TLR4 transfected in HEK293 cells assessed as NFkappaB activation after 20 to 24 hrs by SEAP assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3881376 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as inhibition of LPS-induced receptor activation by measuring NO production at 3 uM after 24 hrs | Mus musculus | 1 | cell-based format | Patent Bioactivity Data |
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