# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3594849 | Binding | Binding affinity to alpha3beta4 nicotine acetylcholine receptor (unknown origin) after 90 mins by radioligand displacement assay | Homo sapiens | 21 | ALA3593203 | protein complex format | Scientific Literature | |
2. | ALA3607040 | Binding | Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes by liquid scintillation counting method | Homo sapiens | 21 | ALA3603735 | cell-based format | Scientific Literature | |
3. | ALA3607131 | Binding | Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 mV by whole-cell patch clamp assay relative to acetylcholine | Homo sapiens | 7 | ALA3603735 | cell-based format | Scientific Literature | |
4. | ALA3607132 | Binding | Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding potential of -70 mV by whole-cell patch clamp assay | Homo sapiens | 4 | ALA3603735 | cell-based format | Scientific Literature | |
5. | ALA3631641 | Binding | Displacement of [3H]-Epibatidine from human aplha3beta4 nAChR expressed in HEK293 cells pre-incubated for 5 mins followed by overnight incubation by radioligand liquid scintillation counter analysis | Homo sapiens | 4 | ALA3627604 | cell-based format | Scientific Literature | |
6. | ALA3751563 | Binding | Partial agonist activity at human alpha3beta4 nAChR expressed in xenopus oocytes assessed as induction of PAM-sensitive desensitization at 30 uM by two-electrode voltage clamp electrophysiology relative to acetylcholine | Homo sapiens | 19 | ALA3745606 | cell-based format | Scientific Literature | |
7. | ALA3751568 | Binding | Antagonist activity at human alpha3beta4 nAChR expressed in xenopus oocytes at 100 uM by two-electrode voltage clamp electrophysiology | Homo sapiens | 1 | ALA3745606 | cell-based format | Scientific Literature | |
8. | ALA3761528 | Binding | Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addition by beta counting analysis | Homo sapiens | 14 | ALA3758078 | cell-based format | Scientific Literature | |
9. | ALA3761534 | Binding | Binding affinity to alpha3beta4 nACh receptor (unknown origin) expressed in Xenopus oocytes | Homo sapiens | 1 | ALA3758078 | cell-based format | Scientific Literature | |
10. | ALA3761538 | Binding | Agonist activity at human alpha3beta4 nACh receptor expressed in rat GHC41 cells assessed as increase in current amplitudes at 0.1 to 100 uM after 2 to 3 days by patch clamp assay relative to acetylcholine | Homo sapiens | 1 | ALA3758078 | cell-based format | Scientific Literature | |
11. | ALA3761539 | Binding | Agonist activity at human alpha3beta4 nACh receptor expressed in rat GH4C1 cells assessed as increase in current amplitudes after 2 to 3 days by patch clamp assay | Homo sapiens | 1 | ALA3758078 | cell-based format | Scientific Literature | |
12. | ALA3761542 | Binding | Antagonist activity at human alpha3beta4 nACh receptor | Homo sapiens | 2 | ALA3758078 | protein complex format | Scientific Literature | |
13. | ALA653226 | Functional | Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretion | 19 | ALA1146803 | assay format | Scientific Literature | ||
14. | ALA843709 | Functional | Recovery from Ach evoked currents at alpha3-beta4 nicotinic acetylcholine receptor at 20 uM concentration | Homo sapiens | 2 | ALA1145812 | assay format | Scientific Literature | |
15. | ALA830259 | Binding | Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta4 | 1 | ALA1142717 | protein complex format | Scientific Literature | ||
16. | ALA839600 | Binding | Inhibition of [3H]epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells | Homo sapiens | 1 | ALA1139609 | cell-based format | Scientific Literature | |
17. | ALA838764 | Binding | Inhibition of [3H]epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of human IMR32 cells | Homo sapiens | 5 | ALA1139503 | cell-based format | Scientific Literature | |
18. | ALA839749 | Binding | Inhibition of [3H]epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells | Homo sapiens | 7 | ALA1139609 | cell-based format | Scientific Literature | |
19. | ALA829047 | Binding | Inhibition of [3H]epibatidine binding to nicotinic acetylcholine receptor alpha3-beta4 of IMR32 cells (-)= Not determined | Homo sapiens | 2 | ALA1139609 | cell-based format | Scientific Literature | |
20. | ALA830026 | Binding | Effective concentration against Nicotinic acetylcholine receptor alpha3-beta4 | Homo sapiens | 6 | ALA1145159 | protein complex format | Scientific Literature |