# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA714426 | Binding | Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes. | Rattus norvegicus | 14 | ALA1126628 | cell membrane format | Scientific Literature | |
2. | ALA841892 | Functional | Percentage inhibition of field stimulated contraction guinea pig ileum (parasympatholytic activity)in presence of test compound (4 mg/L) | Cavia porcellus | 23 | ALA1122227 | tissue-based format | Scientific Literature | |
3. | ALA846205 | Binding | Affinity at muscarinic receptor from rat cortex using [3H]-QNB as radioligand (For atropine Ki(nM)= 3.5+/-0.3) | 2 | ALA1134339 | assay format | Scientific Literature | ||
4. | ALA846206 | Binding | Affinity at muscarinic receptor, (For atropine Ki(nM)= 3.5+/-0.3) | 1 | ALA1134339 | protein format | Scientific Literature | ||
5. | ALA845219 | Binding | Tested for affinity against muscarinic acetylcholine using [3H]quinuclidinyl benzylate in rat brain | 1 | ALA1127053 | tissue-based format | Scientific Literature | ||
6. | ALA845360 | Binding | Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand | 40 | ALA1131552 | cell membrane format | Scientific Literature | ||
7. | ALA845361 | Binding | Binding affinity towards muscarinic receptor using [3H]cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex | 17 | ALA1128858 | tissue-based format | Scientific Literature | ||
8. | ALA844531 | Binding | Binding affinity towards muscarinic receptor using [3H]quinuclidinyl benzilate (QNB) to label antagonist sites in membrane preparations from rat neocortex | 17 | ALA1128858 | assay format | Scientific Literature | ||
9. | ALA844532 | Binding | Compound was evaluated for its ability to displace muscarinic agonist [3H]quinuclidinyl benzilate in rat cortical tissue (RCMD binding assay), at 0.1 uM concentration | 2 | ALA1125978 | assay format | Scientific Literature | ||
10. | ALA844533 | Binding | Compound was evaluated for its ability to displace muscarinic antagonist [3H]cis-methyldioxolane in rat cortical tissue (RQNB binding assay), at 1.0 uM concentration | 2 | ALA1125978 | assay format | Scientific Literature | ||
11. | ALA844534 | Binding | Binding affinity towards muscarinic receptor using [3H]cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex at 100 nM | 1 | ALA1128858 | tissue-based format | Scientific Literature | ||
12. | ALA844535 | Binding | Binding affinity towards muscarinic receptor using [3H]cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex at 1 uM | 3 | ALA1128858 | tissue-based format | Scientific Literature | ||
13. | ALA844536 | Binding | Binding affinity towards muscarinic receptor using [3H]quinuclidinyl benzilate (QNB) to label antagonist sites in membrane preparations from rat neocortex at 100 nM | 4 | ALA1128858 | assay format | Scientific Literature | ||
14. | ALA856162 | Binding | Compound was evaluated for its ability to displace muscarinic agonist [3H]quinuclidinyl benzilate in rat cortical tissue (RCMD binding assay), at 0.1 uM concentration | 8 | ALA1125978 | assay format | Scientific Literature | ||
15. | ALA844537 | Binding | Compound was evaluated for its ability to displace muscarinic antagonist [3H]cis-methyldioxolane in rat cortical tissue (RQNB binding assay), at 1.0 uM concentration | 8 | ALA1125978 | assay format | Scientific Literature | ||
16. | ALA844538 | Binding | Binding affinity towards rat muscarinic receptor | 1 | ALA1128131 | protein format | Scientific Literature | ||
17. | ALA849627 | Binding | Ratio of Ki value for QNB to that of Ki value for Oxo-M. | 46 | ALA1125599 | protein format | Scientific Literature | ||
18. | ALA850046 | Functional | Muscarinic agonist index calculated as [IC50(QNB)/IC50(Oxo-M)] X 0.162 values | 27 | ALA1125247 | assay format | Scientific Literature | ||
19. | ALA882585 | Binding | Relative binding efficacy for muscarinic receptors using QNB and CMD | Rattus norvegicus | 12 | ALA1126443 | protein format | Scientific Literature | |
20. | ALA845465 | Binding | Efficacy ratio was determined against Muscarinic receptor using QNB/ OXO- M | Rattus norvegicus | 10 | ALA1127881 | protein format | Scientific Literature |