| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2020901 | B | Inhibition of Mycobacterium tuberculosis GST-fused PknB expressed in Escherichia coli assessed as GarA substrate phosphorylation after 30 mins | Mycobacterium tuberculosis | 36 | assay format | Scientific Literature | ||
| 2. | ALA1175225 | B | Inhibition of Mycobacterium tuberculosis PKNB at 10 uM | Mycobacterium tuberculosis | 2 | single protein format | Scientific Literature | ||
| 3. | ALA1908450 | B | Binding constant for PKNB(M.tuberculosis) kinase domain | 72 | single protein format | Scientific Literature | |||
| 4. | ALA2212488 | B | Inhibition of Mycobacterium tuberculosis PKNB assessed as residual activity at 10 uM relative to control | Mycobacterium tuberculosis | 1 | single protein format | Scientific Literature | ||
| 5. | ALA3387070 | B | Inhibition of Mycobacterium tuberculosis PknB | Mycobacterium tuberculosis | 16 | single protein format | Scientific Literature | ||
| 6. | ALA4025333 | B | Inhibition of wild-type Mycobacterium tuberculosis H37Rv ATCC 25618 partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Mycobacterium tuberculosis H37Rv | 1 | assay format | Scientific Literature | ||
| 7. | ALA4054907 | B | Inhibition of wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual activity at 50 nM by Kinomescan method relative to control | Mycobacterium tuberculosis | 2 | assay format | Scientific Literature | ||
| 8. | ALA4136605 | B | Inhibition of Mycobacterium tuberculosis PknB (M1 to G279 residues) expressed in Escherichia coli BL21 (DE3) cells using [T-33P]ATP as substrate after 50 mins in presence of GarA by liquid scintillation method | Mycobacterium tuberculosis | 36 | cell-based format | Scientific Literature | ||
| 9. | ALA4224116 | B | Inhibition of Mycobacterium tuberculosis GST-tagged PknB expressed in Escherichia coli assessed as reduction in PknB autophosphorylation at 4.8 uM preincubated for 30 mins followed by [gamma32P]ATP addition measured after 30 mins by scintillation counting method relative to control | Mycobacterium tuberculosis | 2 | assay format | Scientific Literature | ||
| 10. | ALA4224117 | B | Inhibition of Mycobacterium tuberculosis GST-tagged PknB expressed in Escherichia coli assessed as reduction in PknB autophosphorylation at 0.24 to 4.8 uM preincubated for 30 mins followed by [gamma32P]ATP addition measured after 30 mins by scintillation counting method | Mycobacterium tuberculosis | 3 | assay format | Scientific Literature | ||
| 11. | ALA4224118 | B | Inhibition of Mycobacterium tuberculosis PknB (279 residues) expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in PknB autophosphorylation preincubated for 30 mins followed by ATP addition measured after 3 hrs by Kinase Glo luminescence assay | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 12. | ALA4224120 | B | Induction of Mycobacterium tuberculosis GST-tagged PknB autophosphorylation expressed in Escherichia coli at 4.8 uM preincubated for 30 mins followed by [gamma32P]ATP addition measured after 30 mins by scintillation counting method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 13. | ALA4230902 | B | Binding affinity to wild-type Mycobacterium tuberculosis H37Rv ATCC 25618 partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Mycobacterium tuberculosis H37Rv | 1 | assay format | Scientific Literature | ||
| 14. | ALA4308000 | B | Binding affinity to wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 15. | ALA4333585 | B | Binding affinity to wild-type Mycobacterium tuberculosis H37Rv partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Mycobacterium tuberculosis H37Rv | 1 | assay format | Scientific Literature | ||
| 16. | ALA4358080 | B | Binding affinity to wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 17. | ALA4365917 | B | Inhibition of wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 18. | ALA4389430 | B | Inhibition of wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 19. | ALA4389907 | B | Inhibition of wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature | ||
| 20. | ALA4391533 | B | Binding affinity to wild-type Mycobacterium tuberculosis partial length PKNB (M1 to G279 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control | Mycobacterium tuberculosis | 1 | assay format | Scientific Literature |
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