| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA682431 | F | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | 116 | assay format | Scientific Literature | |||
| 2. | ALA2061329 | B | Inhibition of Staphylococcus aureus DNA gyrase B expressed in Escherichia coli BL21(DE3) cells assessed ATP hydrolysis activity after 18 to 24 hrs by malachite green reagent assay | Staphylococcus aureus | 11 | cell-based format | Scientific Literature | ||
| 3. | ALA1926187 | B | Inhibition of ATPase activity of recombinant Staphylococcus aureus DNA gyrase B hybrid tetramer enzyme reconstituted from Escherichia coli GyrA by ammonium molybdate/malachite green phosphate assay | Staphylococcus aureus | 14 | single protein format | Scientific Literature | ||
| 4. | ALA2154061 | B | Inhibition of Staphylococcus aureus DNA gyrase Gyr B subunit by ATPase assay | Staphylococcus aureus | 2 | single protein format | Scientific Literature | ||
| 5. | ALA3239012 | B | Inhibition of ATPase activity in Staphylococcus aureus GyrB tetramer in presence of Escherichia coli GyrA by ammonium molybdate/malachite green-based absorbance assay | Staphylococcus aureus | 39 | single protein format | Scientific Literature | ||
| 6. | ALA3241514 | B | Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity assessed as consumption of inorganic phosphate at 300 uM by PNP-based absorbance assay relative to control | Staphylococcus aureus | 2 | single protein format | Scientific Literature | ||
| 7. | ALA3241515 | B | Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity assessed as consumption of inorganic phosphate at 100 uM by PNP-based absorbance assay relative to control | Staphylococcus aureus | 2 | single protein format | Scientific Literature | ||
| 8. | ALA3241516 | B | Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity assessed as consumption of inorganic phosphate at 30 uM by PNP-based absorbance assay relative to control | Staphylococcus aureus | 2 | single protein format | Scientific Literature | ||
| 9. | ALA3241517 | B | Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity assessed as consumption of inorganic phosphate at 10 uM by PNP-based absorbance assay relative to control | Staphylococcus aureus | 2 | single protein format | Scientific Literature | ||
| 10. | ALA3241518 | B | Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity assessed as consumption of inorganic phosphate by PNP-based absorbance assay | Staphylococcus aureus | 3 | single protein format | Scientific Literature | ||
| 11. | ALA3388390 | B | Inhibition of Staphylococcus aureus DNA gyrase B ATPase activity | Staphylococcus aureus | 53 | single protein format | Scientific Literature | ||
| 12. | ALA3376315 | B | Inhibition of Staphylococcus aureus GyrB assessed reduction in DNA supercoiling activity by malachite green dye based by spectrophotometry | Staphylococcus aureus | 3 | single protein format | Scientific Literature | ||
| 13. | ALA3366704 | B | Inhibition of ATPase activity of Staphylococcus aureus GyrB | Staphylococcus aureus | 70 | single protein format | Scientific Literature | ||
| 14. | ALA3367588 | B | Inhibition of Staphylococcus aureus GyrB at 50 uM | Staphylococcus aureus | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3405735 | B | Inhibition of Staphylococcus aureus GyrB at 100 uM | Staphylococcus aureus | 1 | single protein format | Scientific Literature | ||
| 16. | ALA3630320 | B | Inhibition of Staphylococcus aureus DNA gyrase B assessed as reduction in ATPase activity at 100 uM incubated for 100 mins by inorganic phosphate detection assay | Staphylococcus aureus | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3737854 | B | Inhibition of Staphylococcus aureus DNA GyraseB ATPase activity using linear pBR322 DNA as substrate incubated for 30 mins by fluorescence polarization analysis | Staphylococcus aureus | 39 | single protein format | Scientific Literature | ||
| 18. | ALA3745476 | B | Inhibition of Staphylococcus aureus Gyrase B ATPase activity by fluorescence analysis | Staphylococcus aureus | 29 | single protein format | Scientific Literature | ||
| 19. | ALA3762663 | B | Binding affinity to full length Staphylococcus aureus GyrB by STD-NMR spectroscopic analysis | Staphylococcus aureus | 9 | single protein format | Scientific Literature | ||
| 20. | ALA3812636 | B | Inhibition of Staphylococcus aureus DNA gyraseB ATPase activity using linear pBR322 DNA substrate incubated for 30 mins by fluorescence polarization assay | Staphylococcus aureus | 28 | single protein format | Scientific Literature |
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