# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1936903 | B | Inhibition of human DMT1 expressed in CHO cells assessed as blockage of ferrous influx after 20 mins by calcein fluorescence quenching method | Homo sapiens | 48 | ALA1933041 | cell-based format | Scientific Literature | |
2. | ALA1936912 | B | Inhibition of human DMT1 expressed in CHO cells assessed as effect on ionic current at 10 uM by whole-cell voltage clamp assay | Homo sapiens | 2 | ALA1933041 | cell-based format | Scientific Literature | |
3. | ALA1936913 | B | Inhibition of human DMT1 at 10 uM after 20 mins by calcein quenching fluorescence assay relative to desferoxamine | Homo sapiens | 10 | ALA1933041 | single protein format | Scientific Literature | |
4. | ALA4700245 | B | Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake by Dixon plot analysis | Homo sapiens | 1 | ALA4699420 | cell-based format | Scientific Literature | |
5. | ALA4700246 | B | Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake in presence of saturating iron concentration by Dixon plot analysis | Homo sapiens | 1 | ALA4699420 | cell-based format | Scientific Literature | |
6. | ALA4700248 | B | Inhibition of human DMT1 expressed in Xenopus oocytes assessed as inhibition of channel currents at -50 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 2 | ALA4699420 | cell-based format | Scientific Literature | |
7. | ALA4700256 | B | Inhibition of human DMT1 expressed in HEK293 cells assessed as inhibition of radiolabeled 55Fe2+ uptake incubated for 1 hr by microplate scintillation counting analysis | Homo sapiens | 2 | ALA4699420 | cell-based format | Scientific Literature | |
8. | ALA4700257 | B | Inhibition of human DMT1 expressed in HEK293T cells assessed as inhibition of radiolabeled 55Fe2+ uptake preincubated with compound for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ for 15 mins at extracellular pH of 5.5 by scintillation counting analysis | Homo sapiens | 2 | ALA4699420 | cell-based format | Scientific Literature | |
9. | ALA4700260 | B | Inhibition of human DMT1 expressed in Xenopus laevis oocytes assessed as reduction in radiolabeled 55Fe2+ uptake at 10 uM preincubated for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ and measured after 10 mins by scintillation counting method relative to control | Homo sapiens | 1 | ALA4699420 | cell-based format | Scientific Literature | |
10. | ALA4700261 | B | Inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled 55Fe2+ uptake at 10 uM preincubated with compound for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ for 15 mins at extracellular pH of 5.5 by scintillation counting analysis | Homo sapiens | 1 | ALA4699420 | cell-based format | Scientific Literature |