| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1938115 | B | Inhibition of human MOF expressed in Escherichia coli BL21(DE3) cells using [14C]AC-CoA and histone H4 as substrate after 5 mins by scintillation counting | Homo sapiens | 2 | ALA1933039 | cell-based format | Scientific Literature | |
| 2. | ALA3626896 | B | Inhibition of human MOF at 5 uM | Homo sapiens | 4 | ALA3621044 | single protein format | Scientific Literature | |
| 3. | ALA3738192 | B | Uncompetitive inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Vmax for acetyl coenzyme A at 80 uM (Rvb = 17 +/- 0.7 pmol/min) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 4. | ALA3738193 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A level using histone H4 substrate at 400 uM after 15 mins by CPM fluorescence assay | Homo sapiens | 10 | ALA3734689 | cell-based format | Scientific Literature | |
| 5. | ALA3738194 | B | Uncompetitive inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Vmax for acetyl coenzyme A at 160 uM (Rvb = 17 +/- 0.7 pmol/min) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 6. | ALA3738195 | B | Uncompetitive inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Vmax for acetyl coenzyme A at 240 uM (Rvb = 17 +/- 0.7 pmol/min) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 7. | ALA3738196 | B | Uncompetitive inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Km for acetyl coenzyme A at 80 uM (Rvb = 4.8 +/- 0.5 uM) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 8. | ALA3738197 | B | Uncompetitive inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Km for acetyl coenzyme A at 160 uM (Rvb = 4.8 +/- 0.5 uM) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 9. | ALA3738198 | B | Uncompetitive inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Km for acetyl coenzyme A at 240 uM (Rvb = 4.8 +/- 0.5 uM) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 10. | ALA3738199 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Vmax for histone H4 peptide at 80 uM (Rvb = 13 +/- 0.7 pmol/min) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 11. | ALA3738200 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Vmax for histone H4 peptide at 160 uM (Rvb = 13 +/- 0.7 pmol/min) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 12. | ALA3738201 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as Vmax for histone H4 peptide at 240 uM (Rvb = 13 +/- 0.7 pmol/min) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 13. | ALA3738202 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as half-maximal velocity for histone H4 peptide at 80 uM (Rvb = 36 uM) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 14. | ALA3738203 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as half-maximal velocity for histone H4 peptide at 160 uM (Rvb = 36 uM) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 15. | ALA3738204 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as half-maximal velocity for histone H4 peptide at 240 uM (Rvb = 36 uM) | Homo sapiens | 1 | ALA3734689 | cell-based format | Scientific Literature | |
| 16. | ALA3738205 | B | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A level using histone H4 substrate after 15 mins by CPM fluorescence assay | Homo sapiens | 10 | ALA3734689 | cell-based format | Scientific Literature | |
| 17. | ALA4139703 | B | Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGKGGKGLGKGGAKRHRK-NH2 as substrate after 5 mins in presence of Ac-CoA by fluorescence assay | Homo sapiens | 31 | ALA4138110 | assay format | Scientific Literature | |
| 18. | ALA4139708 | B | Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGKGGKGLGKGGAKRHRK-NH2 as substrate after 5 mins in presence of Ac-CoA and TCEP by fluorescence assay | Homo sapiens | 1 | ALA4138110 | assay format | Scientific Literature | |
| 19. | ALA4139709 | B | Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGKGGKGLGKGGAKRHRK-NH2 as substrate after 5 mins in presence of Ac-CoA and NADH by fluorescence assay | Homo sapiens | 1 | ALA4138110 | assay format | Scientific Literature | |
| 20. | ALA4139710 | B | Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGKGGKGLGKGGAKRHRK-NH2 as substrate after 5 mins in presence of Ac-CoA and NAD+ by fluorescence assay | Homo sapiens | 1 | ALA4138110 | assay format | Scientific Literature |
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