# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1943611 | B | Inhibition of human MLKL in HL-60 cells lysate assessed as reduction of labeling of acyl-phosphate ATP probe at 100 nM | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA3224036 | B | Competitive binding affinity to Myc-tagged MLKL (unknown origin) transfected in human HeLa cells at 20 nM by Western blot analysis in presence of biotin-labeled positive probe | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
3. | ALA4045624 | B | Inhibition of MLKL conserved Lys1 (APVAIKVFK) in human PBMC at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
4. | ALA4045627 | B | Inhibition of MLKL conserved Lys1 (APVAIKVFK) in human PBMC at 0.1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
5. | ALA4118411 | B | Inhibition of MLKL in human SKCO1 cells at 1 uM after 4 hrs using biotin labeled APVAIKVFK probe by mass-spectrometric analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
6. | ALA4378753 | B | Binding affinity to MLKL (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
7. | ALA4378754 | B | Binding affinity to human MLKL by kinome scan based method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
8. | ALA4378756 | B | Binding affinity to MLKL (unknown origin) assessed as increase in thermal stabilization at 10 uM incubated for 30 mins by thermal shift dye based qPCR analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA4406996 | B | Inhibition of MLKL phosphorylation in TNFalpha/smac mimetic/Z-VAD-fmk stimulated human HT-29 cells at 1 uM treated prior to TNFalpha/smac mimetic/Z-VAD-fmk stimulation and measured after 2 to 4 hrs by SDS-PAGE based immunoblot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4804432 | B | Inhibition of MLKL in human NCI-H929 cells by mass spectroscopic analysis | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4804614 | B | Inhibition of MLKL in human NCI-H929 cells at 10 uM by mass spectroscopic analysis relative to control | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4817054 | B | Inhibition of MLKL (unknown origin) polymerization | Homo sapiens | 1 | single protein format | Scientific Literature | ||
13. | ALA4842520 | B | Inhibition of MLKL phosphorylation in Z-VAD-fmk (TSZ)-induced human HT-29 cells at 1 uM measured up to 4 hrs by immunoblotting analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
14. | ALA4842523 | B | Inhibition of MLKL phosphorylation in Z-VAD-fmk (TSZ)-induced human HT-29 cells measured at 4 hrs by immunoblotting analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
15. | ALA4884782 | B | MLKL(MLKLPHY1) Takeda global kinase panel | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
16. | ALA4885073 | B | MLKL(MLKLPHY1) Takeda global kinase panel | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
17. | ALA4885361 | B | MLKL(MLKLPHY1) Takeda global kinase panel | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
18. | ALA5035742 | B | Binding affinity to MLKL N-terminal executioner domain (2 to 154 residues)(unknown origin) assessed as dissociation constant by TROSY-HSQC NMR titration analysis | Homo sapiens | 9 | single protein format | Scientific Literature | ||
19. | ALA5035744 | B | Binding affinity to MLKL N-terminal executioner domain (2 to 154 residues)(unknown origin) assessed as dissociation constant in presence of Nonyl-maltoside by TROSY-HSQC NMR titration analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
20. | ALA5099515 | B | Inhibition of MLKL phosphorylation in TSZ induced human HT-29 cells at 1 uM pretreated with compound followed by TSZ stimulation upto 6 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |