| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1947579 | B | Inhibition of trypanothione reductase in promastigotes of Leishmania infantum MHOM/MA67ITMAP263 extracts assessed as NADPH consumption using trypanothione disulfide as substrate at 1 uM after 5 sec by spectrophotometer | Leishmania infantum | 1 | ALA1944629 | single protein format | Scientific Literature | |
| 2. | ALA1947582 | B | Inhibition of recombinant Leishmania infantum MHOM/MA67ITMAP263 trypanothione reductase assessed as inhibition of NADPH consumption using trypanothione disulfide as substrate at 1 uM after 60 secs by spectrophotometer | Leishmania infantum | 2 | ALA1944629 | single protein format | Scientific Literature | |
| 3. | ALA1947584 | B | Non-competitive inhibition of recombinant Leishmania infantum MHOM/MA67ITMAP263 trypanothione reductase assessed as inhibition of NADPH consumption using trypanothione disulfide as substrate at 1 uM by Michaelis-Menten and Lineweaver-Burk plot analysis | Leishmania infantum | 2 | ALA1944629 | single protein format | Scientific Literature | |
| 4. | ALA4053920 | B | Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence of NADPH | Leishmania infantum | 14 | ALA4052619 | single protein format | Scientific Literature | |
| 5. | ALA4053921 | B | Inhibition of recombinant His/FLAG-tagged Leishmania infantum TryR dimerization assessed as dimer disruption after 1 hr by ELISA | Leishmania infantum | 8 | ALA4052619 | single protein format | Scientific Literature | |
| 6. | ALA4057161 | B | Inhibition of Leishmania infantum trypanothione reductase | Leishmania infantum | 21 | ALA4052757 | single protein format | Scientific Literature | |
| 7. | ALA4134877 | B | Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH addition | Leishmania infantum | 17 | ALA4130478 | single protein format | Scientific Literature | |
| 8. | ALA4134878 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase incubated for 16 hrs in presence of dimerization buffer by ELISA | Leishmania infantum | 17 | ALA4130478 | single protein format | Scientific Literature | |
| 9. | ALA4198087 | B | Inhibition of recombinant Leishmania infantum trypanothione reductase using T[S]2 as substrate preincubated for 5 mins followed by substrate and NADPH addition measured for 1 hr | Leishmania infantum | 5 | ALA4196062 | single protein format | Scientific Literature | |
| 10. | ALA4198088 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase incubated for 16 hrs by ELISA | Leishmania infantum | 3 | ALA4196062 | single protein format | Scientific Literature | |
| 11. | ALA4198097 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 9.375 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | ALA4196062 | single protein format | Scientific Literature | |
| 12. | ALA4198098 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 18.75 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | ALA4196062 | single protein format | Scientific Literature | |
| 13. | ALA4198099 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 37.5 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | ALA4196062 | single protein format | Scientific Literature | |
| 14. | ALA4198100 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 75 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | ALA4196062 | single protein format | Scientific Literature | |
| 15. | ALA4824242 | B | Inhibition of recombinant His-tagged Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL2(DE3) using TS2 as substrate by spectrophotometric assay | Leishmania infantum | 29 | ALA4823264 | assay format | Scientific Literature | |
| 16. | ALA4824243 | B | Inhibition of recombinant Leishmania infantum TryR assessed as apparent inhibition constant for initial EI complex in presence of 3.1 uM TS2 by DTNB-reagent based spectrophotometric method | Leishmania infantum | 1 | ALA4823264 | single protein format | Scientific Literature | |
| 17. | ALA4824244 | B | Inhibition of recombinant His-FLAG-tagged Leishmania infantum TryR dimerization expressed in Escherichia coli BL2(DE3) assessed as reduction in TryR dimer using TS2 as substrate after 16 hrs by ELISA | Leishmania infantum | 27 | ALA4823264 | assay format | Scientific Literature | |
| 18. | ALA4824245 | B | Inhibition of recombinant His-FLAG-tagged Leishmania infantum TryR dimerization expressed in Escherichia coli BL2(DE3) assessed as reduction in TryR dimer at 20 uM using TS2 as substrate after 16 hrs by ELISA relative to control | Leishmania infantum | 4 | ALA4823264 | assay format | Scientific Literature | |
| 19. | ALA4824247 | B | Inhibition of recombinant Leishmania infantum TryR assessed as overall apparent inhibition constant in presence of 3.1 uM TS2 by DTNB-reagent based spectrophotometric method | Leishmania infantum | 1 | ALA4823264 | single protein format | Scientific Literature | |
| 20. | ALA4824248 | B | Inhibition of recombinant Leishmania infantum TryR assessed as apparent inhibition constant for initial EI complex in presence of 6.2 uM TS2 by DTNB-reagent based spectrophotometric method | Leishmania infantum | 1 | ALA4823264 | single protein format | Scientific Literature |
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