# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1953940 | B | Binding affinity to human recombinant DcpS by fluorescence quenching titration method | Homo sapiens | 13 | ALA1949618 | single protein format | Scientific Literature | |
2. | ALA3608039 | A | Stability of the compound assessed as human DcpS-mediated compound hydrolysis at 40 uM after 10 to 180 mins by HPLC analysis | Homo sapiens | 11 | ALA3603763 | single protein format | Scientific Literature | |
3. | ALA3608040 | A | Stability of the compound assessed as human DcpS-mediated compound hydrolysis at 40 uM after 180 mins by HPLC analysis | Homo sapiens | 2 | ALA3603763 | single protein format | Scientific Literature | |
4. | ALA3992392 | B | Inhibition of DcpS in human 3813 cell lysate derived from type 1 SMA patient assessed as increase in SMN protein expression at 10 to 1000 nM after 5 days in Western blot analysis | Homo sapiens | 2 | ALA3991949 | assay format | Patent Bioactivity Data | |
5. | ALA3992393 | B | Binding affinity to recombinant human N-terminal GST-tagged DcpS expressed in baculovirus-infected Sf9 insect cells at 100 nM after 90 mins in presence of [125I]-streptavidin by microarray assay | Homo sapiens | 1 | ALA3991949 | cell-based format | Patent Bioactivity Data | |
6. | ALA3992394 | B | Displacement of [125I]-(4-((2,4-diaminoquinazolin-5-yloxy)methyl)piperidin-1-yl)(3-iodophenyl)methanone from recombinant human N-terminal GST-tagged DcpS expressed in baculovirus-infected Sf9 insect cells at 10 uM after 90 mins in presence of [125I]-streptavidin by microarray assay | Homo sapiens | 4 | ALA3991949 | cell-based format | Patent Bioactivity Data | |
7. | ALA3992395 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 1.6 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 45%) | Homo sapiens | 2 | ALA3991949 | single protein format | Patent Bioactivity Data | |
8. | ALA3992396 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 8 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 45%) | Homo sapiens | 2 | ALA3991949 | single protein format | Patent Bioactivity Data | |
9. | ALA3992397 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 40 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 45%) | Homo sapiens | 2 | ALA3991949 | single protein format | Patent Bioactivity Data | |
10. | ALA3992398 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 200 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 45%) | Homo sapiens | 2 | ALA3991949 | single protein format | Patent Bioactivity Data | |
11. | ALA3992399 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as reduction in hydrolysis of m7GpppG to m7G using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay | Homo sapiens | 9 | ALA3991949 | single protein format | Patent Bioactivity Data | |
12. | ALA3992422 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 1.6 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 62%) | Homo sapiens | 1 | ALA3991949 | single protein format | Patent Bioactivity Data | |
13. | ALA3992423 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 8 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 62%) | Homo sapiens | 1 | ALA3991949 | single protein format | Patent Bioactivity Data | |
14. | ALA3992424 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 40 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 62%) | Homo sapiens | 1 | ALA3991949 | single protein format | Patent Bioactivity Data | |
15. | ALA3992425 | B | Inhibition of recombinant flag-tagged DcpS (unknown origin) decapping activity assessed as hydrolysis of m7GpppG to m7G at 200 nM using unlabeled cap structure as substrate after 30 secs by PEI cellulose thin-layer chromatographic assay (Rvb = 62%) | Homo sapiens | 1 | ALA3991949 | single protein format | Patent Bioactivity Data | |
16. | ALA4010335 | B | Inhibition of human DcpS assessed as increase in SMN2 promoter activity | Homo sapiens | 29 | ALA4007459 | single protein format | Scientific Literature | |
17. | ALA4182516 | B | Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assay | Homo sapiens | 6 | ALA4177717 | single protein format | Scientific Literature | |
18. | ALA4182520 | B | Inhibition of human DCPS using m7GMPF assessed as reduction in conversion of m7GpppG to GDP at 200 uM after 45 mins in presence of human cN3B by HPLC method | Homo sapiens | 1 | ALA4177717 | single protein format | Scientific Literature | |
19. | ALA4351061 | B | Inhibition of DcpS (unknown origin) using m7GpppA as substrate by ELISA | Homo sapiens | 2 | ALA4350951 | single protein format | Scientific Literature | |
20. | ALA4623586 | A | Prodrug activation assessed as recombinant human DcpS mediated compound hydrolysis at 30 uM measured up to 120 mins by RP-HPLC analysis | Homo sapiens | 6 | ALA4622862 | single protein format | Scientific Literature |