# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1961798 | B | Increased REV-ERB-alpha LBD dependent repressor activity in HEK293 cell reporter assay | 3 | ALA1961794 | cell-based format | Scientific Literature | ||
2. | ALA1961800 | F | REV-ERB-alpha mediated transcriptional suppression at Bmal1 promoter in HEK293 cell reporter assay | 2 | ALA1961794 | cell-based format | Scientific Literature | ||
3. | ALA1961801 | B | Dissociation constant for binding to REV-ERB-alpha by circular dichroism | 1 | ALA1961794 | single protein format | Scientific Literature | ||
4. | ALA1961802 | F | Recruitment of co-repressor NcoR1 to REV-ERB-alpha | 2 | ALA1961794 | assay format | Scientific Literature | ||
5. | ALA2034240 | F | Agonist activity at Rev-erbalpha assessed as NCoR recruitment by FRET assay | 1 | ALA2029304 | assay format | Scientific Literature | ||
6. | ALA2034241 | F | Agonist activity at Rev-erbalpha assessed as repression of transcription at 10 uM by luciferase-reporter gene assay relative to control | 51 | ALA2029304 | assay format | Scientific Literature | ||
7. | ALA2034242 | F | Agonist activity at Rev-erbalpha assessed as repression of transcription by luciferase-reporter gene assay | 51 | ALA2029304 | assay format | Scientific Literature | ||
8. | ALA2060741 | F | Agonist activity at Rev-Erbalpha expressed in HEK293 cells coexpressing BamII promoter assessed as repression of transcription after 24 hrs by dual-Glo luciferase assay | Homo sapiens | 47 | ALA2057134 | cell-based format | Scientific Literature | |
9. | ALA2059914 | F | Agonist activity at Rev-Erbalpha expressed in HEK293 cells coexpressing BamII promoter assessed as repression of transcription at 10 uM after 24 hrs by dual-Glo luciferase assay relative to control | Homo sapiens | 47 | ALA2057134 | cell-based format | Scientific Literature | |
10. | ALA2059915 | B | Agonist activity at Rev-Erbalpha expressed in HEK293 cells coexpressing Gal4 ligand binding domain assessed as inhibition of transcription after 24 hrs by dual-Glo luciferase assay | Homo sapiens | 1 | ALA2057134 | cell-based format | Scientific Literature | |
11. | ALA2384427 | B | Agonist activity at REV-ERBalpha in human THP1 cells assessed as downregulation of LPS-stimulated IL-6 mRNA expression at 1 uM after 6 hrs by RT-qPCR analysis | Homo sapiens | 4 | ALA2380244 | cell-based format | Scientific Literature | |
12. | ALA2384428 | B | Agonist activity at REV-ERBalpha in human U2OS cells assessed as suppression of BMAL1 oscillation measured for 72 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA2380244 | cell-based format | Scientific Literature | |
13. | ALA2384429 | B | Agonist activity at REV-ERBalpha in human U2OS cells assessed as delay of peak of second cycle at 20 uM by luciferase reporter gene assay relative to DMSO-treated control | Homo sapiens | 18 | ALA2380244 | cell-based format | Scientific Literature | |
14. | ALA2384430 | B | Agonist activity at REV-ERBalpha in human U2OS cells assessed as suppression of BMAL1 expression at 20 uM after 40 hrs by luciferase reporter gene assay relative to DMSO-treated control | Homo sapiens | 18 | ALA2380244 | cell-based format | Scientific Literature | |
15. | ALA2384560 | B | Agonist activity at REV-ERBalpha in human THP1 cells assessed as downregulation of LPS-stimulated IL-6 mRNA expression at 10 uM after 6 hrs by RT-qPCR analysis | Homo sapiens | 2 | ALA2380244 | cell-based format | Scientific Literature | |
16. | ALA2384563 | B | Agonist activity at biotinylated REV-ERBalpha (unknown origin) assessed as biotinylated PGC1-beta peptide recruitment after 20 mins by Greiner assay | Homo sapiens | 3 | ALA2380244 | single protein format | Scientific Literature | |
17. | ALA2384564 | B | Agonist activity at biotinylated REV-ERBalpha (unknown origin) assessed as increase in biotinylated NCOR peptide recruitment at 10 mM after 1 hr by FRET assay relative to control | Homo sapiens | 26 | ALA2380244 | single protein format | Scientific Literature | |
18. | ALA2384565 | B | Agonist activity at biotinylated REV-ERBalpha (unknown origin) assessed as increase in biotinylated NCOR peptide recruitment after 1 hr by FRET assay | Homo sapiens | 26 | ALA2380244 | single protein format | Scientific Literature | |
19. | ALA4727677 | B | Agonist activity at Rev-Erb alpha (unknown origin) by FRET assay | Homo sapiens | 17 | ALA4725320 | single protein format | Scientific Literature | |
20. | ALA4727678 | B | Agonist activity at Rev-Erb alpha (unknown origin) by BMAL1-luciferase reporter assay | Homo sapiens | 4 | ALA4725320 | single protein format | Scientific Literature |