| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1961850 | B | Effect on TLX(NR2E1) dependent reporter activity in HEK293 cells at 20 uM | 2 | cell-based format | Scientific Literature | |||
| 2. | ALA5033029 | B | Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as fold decrease in reporter activity at 100 uM measured after 14 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 3. | ALA5033030 | B | Inverse agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as fold decrease in reporter activity at 100 uM by luciferase reporter gene assay relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA5033031 | B | Stabilization of human recombinant TLX LBD assessed as change in melting temperature at 500 uM by DSF assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 5. | ALA5033032 | B | Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured after 14 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 6. | ALA5033033 | B | Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as remaining activity measured after 14 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 7. | ALA5033034 | B | Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as fold increase in reporter activity at 100 uM by luciferase reporter gene assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA5033035 | B | Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as decrease in reporter activity at 100 uM by luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5033037 | B | Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activity incubated for 14 hrs by Dual-glo luciferase | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 10. | ALA5033038 | B | Binding affinity to TLX LBD expressed in His6-tagged Escherichia coli Rosetta assessed as binding constant measured after 300 sec at 200 mM by isothermal titration calorimetry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA5033047 | B | Agonist activity at human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 incubated for 14 hrs at 100 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5033048 | B | Agonist activity at human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 incubated for 14 hrs at 300 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5033049 | B | Inverse agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as fold increase in reporter activity at 100 uM measured after 14 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA5033050 | B | Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as fold increase in reporter activity at 100 uM by luciferase reporter gene assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 15. | ALA5044481 | B | Agonist activity at human Gal4-fused TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP16 assessed as repressor activity of receptor by measuring decrease in reporter activity measured after 14 hrs by Dual-Glo Luciferase assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 16. | ALA5044482 | B | Agonist activity at human full length Gal4-fused TLX transfected in human HEK293T cells coexpressing pFR-TAE-Luc assessed as repressor activity of receptor by measuring decrease in reporter activity by dual-glo luciferase assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5044483 | B | Destabilization of recombinant TLX LBD (unknown origin) assessed as change in melting temperature at 100 uM by isothermal titration calorimetry | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA5044484 | B | Binding affinity to recombinant TLX LBD (unknown origin) by differential scanning fluorometry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA5044485 | B | Destabilization of recombinant TLX LBD (unknown origin) assessed as change in enthalpy at 100 uM by isothermal titration calorimetry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA5044486 | B | Agonist activity at TLX (unknown origin) assessed as induction of receptor oligomerization using sGFP-labeled TLX LBD as acceptor and biotin TLX LBD as donor measured after 20 hrs incubation at RT and 2 hrs at 37 degC by HTRF assay | Homo sapiens | 1 | single protein format | Scientific Literature |
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