| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1963857 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Cherrypicks in WT IDH1. (Class of assay: confirmatory) | 192 | assay format | PubChem BioAssays | |||
| 2. | ALA1963873 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Cherrypicks Autofluorescence Interference. (Class of assay: confirmatory) | 4 | assay format | PubChem BioAssays | |||
| 3. | ALA1964002 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | 3,373 | assay format | PubChem BioAssays | |||
| 4. | ALA1964082 | F | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) | 712 | assay format | PubChem BioAssays | |||
| 5. | ALA5254913 | B | Binding affinity to human IDH1 assessed as binding constant (Koff) in presence of NADPH and alpha-ketoglutarate by spectrophotometry analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA5254914 | B | Binding affinity to human IDH1 assessed as binding constant (Kon) in presence of NADPH and alpha-ketoglutarate by spectrophotometry analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA2188252 | B | Inhibition of wild type IDH1 using DL-isocitrate as substrate by resazurin-based fluorimetric analysis relative to control | 5 | single protein format | Scientific Literature | |||
| 8. | ALA2188253 | B | Inhibition of wild type IDH1 using DL-isocitrate as substrate by resazurin-based fluorimetric analysis | 8 | single protein format | Scientific Literature | |||
| 9. | ALA2188255 | B | Inhibition of IDH1 R132C mutant overexpressed in human HT1080 cells assessed as inhibition of 2-hydroxyglutarate production after 48 hrs by LC/MS analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 10. | ALA2188256 | B | Inhibition of IDH1 R132C mutant using alpha-ketoglutarate as substrate after 60 mins by resazurin-based fluorimetric analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 11. | ALA2188258 | B | Inhibition of IDH1 R132H mutant expressed in human U87 cells assessed as inhibition of 2-hydroxyglutarate production after 48 hrs by LC/MS analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 12. | ALA2188259 | B | Uncompetitive inhibition of IDH1 R132H mutant using NADPH as substrate by stopped-flow spectrophotometric analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA2188260 | B | Competitive inhibition of IDH1 R132H mutant using alpha-ketoglutarate as substrate by stopped-flow spectrophotometric analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA2188261 | B | Reversible inhibition of IDH1 R132H mutant using alpha-ketoglutarate as substrate by stopped-flow spectrophotometric analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA2188262 | B | Inhibition of IDH1 R132H mutant using alpha-ketoglutarate as substrate after 60 mins by resazurin-based fluorimetric analysis | Homo sapiens | 36 | assay format | Scientific Literature | ||
| 16. | ALA2354311 | F | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | 31,581 | cell-based format | PubChem BioAssays | |||
| 17. | ALA2390486 | B | Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as production of D-2-hydroxyglutaric acid formation after 48 hrs by HPLC-MS method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2390489 | B | Inhibition of wild type IDH1 (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 19. | ALA2390491 | B | Inhibition of recombinant IDH1 R132C mutant (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 20. | ALA2390492 | B | Inhibition of recombinant IDH1 R132H mutant (unknown origin) expressed in Escherichia coli BL21 using alpha-ketoglutarate as substrate incubated for 5 mins prior to substrate addition measured every 30 secs | Homo sapiens | 6 | assay format | Scientific Literature |
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