| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2015576 | B | Binding affinity to human recombinant Trx-1 expressed in Escherichia coli by mass spectrometry analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA2015577 | B | Inhibition of human recombinant Trx-1 expressed in Escherichia coli after 30 to 90 mins preincubation by insulin reduction assay in presence of thioredoxin reductase | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA2015579 | B | Inhibition of human recombinant Trx-1 expressed in Escherichia coli at 2.5 to 20 uM by insulin reduction assay in presence of thioredoxin reductase | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA2015657 | B | Inhibition of thioredoxin in human HeLa cells cotransfected with p-NFkB-luc assessed as inhibition of TNF/IFN-gamma-induced activation of NF-kB after 6 hrs by luciferase reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA2015658 | B | Inhibition of thioredoxin in human HeLa cells cotransfected with p-AP1-luc assessed as inhibition of ionomycin-induced AP-1 promoter activity after 6 hrs by luciferase reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA2015659 | B | Inhibition of thioredoxin in human HeLa cells assessed as decrease of H2O2 scavenging activity by measuring CM-H2DCFDA fluorescence at 10 uM after 4 hrs by flow cytometeric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA2212211 | B | Covalent binding affinity to human recombinant TRX-1 C assessed as modification in C62/C69/C73 residues by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA2212212 | B | Inhibition of human recombinant TRX-1 by insulin reduction assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA2212214 | B | Inhibition of TRX1 in human SMMC-7221 cells after 2 hrs by insulin reduction assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA2212216 | B | Inhibition of human recombinant TRX-1 up to 60 mins by insulin reduction assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA2212218 | B | Covalent binding affinity to TRX-1 in human SMMC-7221 cells assessed as compound-TRX-1 adduct formation at 3 uM after 2 hrs by immunoblotting in presence of GSH | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA2212220 | B | Covalent binding affinity to TRX-1 in human SMMC-7221 cells at 3 uM after 2 hrs by immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA2212222 | B | Covalent binding affinity to human recombinant TRX-1 assessed as change in protein configuration at 50 uM by LC-ESIQTOF mass spectrometry | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA2212224 | B | Covalent binding affinity to human recombinant TRX-1 assessed as change in protein configuration at 0.1 mM by MALDITOF mass spectrometry | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 15. | ALA2319792 | B | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 16. | ALA2319793 | B | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation at 25 uM after 3 hrs by fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA2319794 | B | Inhibition of human thioredoxin relative to DTT | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 18. | ALA2319795 | B | Inhibition of wild type human thioredoxin | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 19. | ALA2319796 | B | Inhibition of human thioredoxin W31A mutant | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA2319797 | B | Inhibition of wild type human thioredoxin by insulin turbidity assay | Homo sapiens | 1 | single protein format | Scientific Literature |
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