# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1220283 | B | Inhibition of TGFR1-mediated Smad-2 phosphorylation in TGFbeta1-stimulated mouse PASMC at => 20 uM treated 30 mins before TGFbeta1 challenge measured after 30 mins by immunoblot analysis | Mus musculus | 1 | ALA1212693 | single protein format | Scientific Literature | |
2. | ALA2026333 | B | Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assay | Mus musculus | 10 | ALA2021874 | cell-based format | Scientific Literature | |
3. | ALA2091174 | B | Inhibition of ALK5 activity in mouse NMuMG cells assessed as TGFbeta-induced phosphorylation of Smad2 at 0.1 to 0.5 uM after 1 hr by Western blot analysis | Mus musculus | 2 | ALA2086340 | cell-based format | Scientific Literature | |
4. | ALA3270799 | B | Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assay | Mus musculus | 4 | ALA3259733 | cell-based format | Scientific Literature | |
5. | ALA3998843 | A | Inhibition of ALK5 in mouse C2C12 cells assessed as decrease in TGFbeta1-induced Smad1/5 phosphorylation at 0.1 uM by Western blot method | Mus musculus | 1 | ALA3997792 | cell-based format | Scientific Literature | |
6. | ALA3998844 | A | Inhibition of ALK5 in mouse C2C12 cells assessed as decrease in TGFbeta1-induced Smad1/5 phosphorylation at 10 uM by Western blot method | Mus musculus | 1 | ALA3997792 | cell-based format | Scientific Literature | |
7. | ALA3998845 | A | Inhibition of ALK5 in mouse C2C12 cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation at 0.1 to 10 uM by Western blot method | Mus musculus | 2 | ALA3997792 | cell-based format | Scientific Literature | |
8. | ALA3998868 | A | Inhibition of ALK5 in mouse C2C12 assessed as decrease in TGFbeta1-induced Smad1/5 phosphorylation at 0.1 to 10 uM by Western blot method | Mus musculus | 1 | ALA3997792 | single protein format | Scientific Literature | |
9. | ALA4339043 | B | Inhibition of TGFbetaR1 in TGFbeta-stimulated mouse NIH3T3 cells assessed as reduction in SMAD3 phosphorylation | Mus musculus | 1 | ALA4334552 | cell-based format | Scientific Literature | |
10. | ALA4339089 | B | Inhibition of TGFBR1 in mouse whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylation | Mus musculus | 1 | ALA4334552 | tissue-based format | Scientific Literature | |
11. | ALA4769707 | B | Inhibition of TGF-beta type 1 receptor in mouse NIH3T3 cells expressing Luc-Smad 2/3 measured after 24 hrs incubation by cell based Bright-Glo Luciferase assay | Mus musculus | 28 | ALA4765311 | cell-based format | Scientific Literature |