# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1219278 | Binding | Inhibition of human RAD51 assessed as concentration required for half dissociation of protein/single-stranded DNA complex formation by fluorescence polarimetry | Homo sapiens | 6 | ALA1212926 | single protein format | Scientific Literature | |
2. | ALA1219279 | Binding | Binding affinity to human RAD51 by isothermal titration calorimetry | Homo sapiens | 5 | ALA1212926 | single protein format | Scientific Literature | |
3. | ALA1219280 | Binding | Inhibition of human RAD51 assessed as dissociation of protein/single-stranded DNA complex formation by fluorescence polarimetry | Homo sapiens | 5 | ALA1212926 | single protein format | Scientific Literature | |
4. | ALA1219281 | Binding | Inhibition of human RAD51 assessed as dissociation of protein/single-stranded poly-(d-epsilonA) complex formation by fluorescence polarimetry | Homo sapiens | 6 | ALA1212926 | single protein format | Scientific Literature | |
5. | ALA1219282 | Binding | Inhibition of human RAD51 assessed as dissociation of protein/single-stranded oligo(AGT)12 complex formation by fluorescence polarimetry | Homo sapiens | 5 | ALA1212926 | single protein format | Scientific Literature | |
6. | ALA1219283 | Binding | Binding affinity to human RAD51 assessed as dissociation of protein/single-stranded phiX174 DNA complex formation at 10 uM by electron microscopy | Homo sapiens | 1 | ALA1212926 | single protein format | Scientific Literature | |
7. | ALA1219284 | Binding | Binding affinity to human RAD51 assessed as dissociation of protein/single-stranded phiX174 DNA complex formation at 50 uM by electron microscopy | Homo sapiens | 1 | ALA1212926 | single protein format | Scientific Literature | |
8. | ALA1219285 | Binding | Inhibition of human RAD51-mediated 58-mer single-stranded DNA strand exchange activity at 5 to 15 uM after 1 hr by PAGE | Homo sapiens | 6 | ALA1212926 | single protein format | Scientific Literature | |
9. | ALA1219286 | Binding | Binding affinity to human RAD51 at 40 uM by circular dichroism assay | Homo sapiens | 7 | ALA1212926 | single protein format | Scientific Literature | |
10. | ALA4386977 | Binding | Inhibition of human RAD51 | Homo sapiens | 1 | ALA4385635 | single protein format | Scientific Literature | |
11. | ALA3377960 | Binding | Induction of RAD51 in cisplatin-treated neonatal human skin fibroblast assessed as increase in survival at 7.5 uM relative to untreated control | Homo sapiens | 1 | ALA3352588 | single protein format | Scientific Literature | |
12. | ALA3377961 | Binding | Inhibition of RAD51 in human HeLa cells expressing DR-GFP construct assessed as reduction in DSP-induced homologous recombination at 20 uM | Homo sapiens | 1 | ALA3352588 | cell-based format | Scientific Literature | |
13. | ALA3377962 | Binding | Inhibition of RAD51 in human MCF7 cells assessed as reduction in IR-induced RAD51 foci formation at 20 uM | Homo sapiens | 1 | ALA3352588 | cell-based format | Scientific Literature | |
14. | ALA3377963 | Binding | Inhibition of RAD51 (unknown origin) expressed in human HEK293 cells expressing DR-GFP construct assessed as inhibition of gene conversion at 5 to 20 uM relative to untreated control | Homo sapiens | 1 | ALA3352588 | cell-based format | Scientific Literature | |
15. | ALA3377964 | Binding | Inhibition of RAD51 (unknown origin) expressed in human HEK293 cells assessed as inhibition of IR-induced RAD51 foci formation at 25 to 50 uM relative to untreated control | Homo sapiens | 1 | ALA3352588 | cell-based format | Scientific Literature | |
16. | ALA4417893 | Binding | Inhibition of RAD51 (unknown origin) assessed as inhibition of DNA pairing by measuring D-loop formation between [32P]-ssDNA and homologous supercoiled pUC19 DNA at 30 uM incubated for 15 mins by gel electrophoresis method relative to control | Homo sapiens | 17 | ALA4417629 | single protein format | Patent Bioactivity Data | |
17. | ALA4417896 | Binding | Inhibition of RAD51 (unknown origin) assessed as inhibition of DNA pairing by measuring D-loop formation between [32P]-ssDNA and homologous supercoiled pUC19 DNA at 10 times RAD52 IC50 incubated for 15 mins by gel electrophoresis method relative to control | Homo sapiens | 17 | ALA4417629 | single protein format | Patent Bioactivity Data | |
18. | ALA2039416 | Binding | Inhibition of human RAD51-mediated DNA strand exchange at 10 to 100 microM using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay | Homo sapiens | 1 | ALA2034898 | single protein format | Scientific Literature | |
19. | ALA2039418 | Binding | Inhibition of human RAD51-mediated DNA branch migration at 10 to 100 microM using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assay | Homo sapiens | 1 | ALA2034898 | single protein format | Scientific Literature | |
20. | ALA2039420 | Binding | Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay | Homo sapiens | 1 | ALA2034898 | single protein format | Scientific Literature |