| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2077069 | F | TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytes | Xenopus laevis | 6 | cell-based format | TP-search Transporter Database | ||
| 2. | ALA2076227 | F | TP_TRANSPORTER: uptake in Xenopus laevis oocytes | Xenopus laevis | 18 | cell-based format | TP-search Transporter Database | ||
| 3. | ALA1226691 | B | Inhibition of human MCT4 expressed in INS1 cells assessed as reduction in intracellular acidification at 100 nM after 1 hr by L-Lactate uptake based BCECF staining | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA2443718 | B | Ratio of alpha-cyano-4-hydroxycinnamate IC50 to compound IC50 for MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA2444903 | B | Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA2444904 | B | Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 7. | ALA3363654 | B | Inhibition of MCT4 (unknown origin) overexpressed in human MCF7 cells assessed as inhibition of transporter-mediated [14C]lactate transport after 10 mins by scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4886125 | B | Fluorescence Cross Correlation Spectroscopy (FCCS) human | Homo sapiens | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
| 9. | ALA4886127 | B | Lactate efflux inhibition assay (MDA-MB-231) | Homo sapiens | 2 | single protein format | Donated Chemical Probes - SGC Frankfurt | ||
| 10. | ALA5209614 | F | Substrate uptake by the monocarboxylate transporter 4 (MCT4, SLC16A3) as assessed by a sensor pH-sensitive genetically encoded fluorescent sensor (pHAxensor) in HEK-293 JumpIN-SLC16A3 cells (PubChem AID: 1794833) | Homo sapiens | 1 | cell-based format | RESOLUTE - Research Empowerment on Solute Carriers | ||
| 11. | ALA5216042 | B | Inhibition of MCT4 in human NCI-H358 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA5216043 | B | Inhibition of MCT4 in human MDA-MB-231 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA5234414 | B | Inhibition of MCT4 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA5234416 | B | Inhibition of MCT4 (unknown origin) assessed as reduction in [14C]lactate uptake incubated for 20 mins by liquid scintillation counting analysis | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 15. | ALA5234426 | B | Inhibition of MCT4 in human MDA-MB-231 cells by BCECF-AM dye based fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA5234428 | B | Binding affinity to human MCT4 expressed in Xenopus laevis oocytes assessed as inhibition constant in presence of [14C]lactate by fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5234429 | B | Binding affinity to human MCT4 expressed in Xenopus laevis oocytes assessed as Km incubated for 10 mins in presence of [14C]lactate by Michaelis-Menten analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5242438 | B | Inhibition of human MCT4 in human MDA-MB-231 cells assessed as inhibition of lactate efflux preincubated for 30 mins followed by D(+)glucose and measured after 4 hrs by dialysis based UHPLC-ESI-Q-Orbitrap-MS analysis | Homo sapiens | 73 | cell-based format | Scientific Literature | ||
| 19. | ALA5242447 | B | Binding affinity to full-length C-terminal GFP-tagged human MCT4 incubated for 1 hrs by fluorescence cross-correlation spectroscopy analysis | Homo sapiens | 13 | single protein format | Scientific Literature | ||
| 20. | ALA5242448 | B | Binding affinity to full-length C-terminal GFP-tagged human MCT4 assessed as equilibrium dissociation constant incubated for 1 hrs by fluorescence cross-correlation spectroscopy analysis | Homo sapiens | 1 | single protein format | Scientific Literature |
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