| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA678208 | F | Dose affording 50% of maximum transactivation for ecdysone receptor from Bombyx mori (BmEcR) and a beta-galactosidase reporter gene in HEK293 cell-line | Bombyx mori | 19 | ALA1136517 | cell-based format | Scientific Literature | |
| 2. | ALA678209 | F | Agonist activity against Bombyx mori ecdysone receptor | Bombyx mori | 39 | ALA1136556 | assay format | Scientific Literature | |
| 3. | ALA682099 | F | Dose affording 50% of maximum transactivation for ecdysone receptor from Choristoneura fumiferana (CfEcR) and a luciferase reporter gene in CHO cells; Not tested | Choristoneura fumiferana | 1 | ALA1136517 | cell-based format | Scientific Literature | |
| 4. | ALA850009 | F | Ratio of maximum level of gene expression (ecdysone receptor and beta-galactosidase receptor) of compound to maximum level of gene expression with GSTM-E expressed as RMFI | Bombyx mori | 19 | ALA1136517 | assay format | Scientific Literature | |
| 5. | ALA1243413 | B | Activation of Bombyx mori Ecdysone receptor V454I and Y474E mutant (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) at 50 uM exposed for 2 to 6 hrs at 4 hrs post fertilization by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 6. | ALA1243414 | B | Induction of nuclear translocation of Bombyx mori Ecdysone receptor V454I and Y474E mutant (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) at 1 uM exposed for 30 mins at 4 hrs post fertilization by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 7. | ALA1243415 | B | Activation of Bombyx mori Ecdysone receptor V454I and Y474E mutant (amino acids 272-606)-mediated myl7 gene expression expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) assessed as myl7-promoter driven heart specific GFP expression at 10 uM exposed during 3 to 48 hrs post fertilization by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 8. | ALA1243416 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 9. | ALA1243417 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-456) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 10. | ALA1243418 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-468) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 11. | ALA1243419 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-476) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 12. | ALA1243420 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (456-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 13. | ALA1243421 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 14. | ALA1243422 | B | Activation of Bombyx mori Ecdysone receptor V454I and Y474E mutant (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (456-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 15. | ALA1243423 | B | Activation of Bombyx mori Ecdysone receptor V454I and Y474E mutant (amino acids 272-606) expressed in AB zebrafish embryos transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (468-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 1 | ALA1240322 | assay format | Scientific Literature | |
| 16. | ALA1243424 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 2 | ALA1240322 | cell-based format | Scientific Literature | |
| 17. | ALA1243597 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-456) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 2 | ALA1240322 | cell-based format | Scientific Literature | |
| 18. | ALA1243598 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-468) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 2 | ALA1240322 | cell-based format | Scientific Literature | |
| 19. | ALA1243599 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (413-476) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 2 | ALA1240322 | cell-based format | Scientific Literature | |
| 20. | ALA1243600 | B | Activation of Bombyx mori Ecdysone receptor (amino acids 272-606) expressed in HEK293 cells transfected with cytomegalovirus promoter-driven expression construct encoding chimeric transactivator composed of DBD and homodimerization domains of yeast Gal4 (amino acids 1-146) and VP16 activation domain (amino acids (456-490) at 10 uM exposed for 16 hrs by Gal4 dependent luciferase reportre gene assay relative to untreated control | Bombyx mori | 2 | ALA1240322 | cell-based format | Scientific Literature |
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