# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3584059 | Binding | Inhibition of PDE4 (unknown origin) | Homo sapiens | 1 | ALA3580651 | protein format | Scientific Literature | |
2. | ALA3624184 | Binding | Inhibition of PDE4 (unknown origin) | Homo sapiens | 1 | ALA3621135 | protein format | Scientific Literature | |
3. | ALA3625945 | Binding | Inhibition of human PDE4 at 10 uM relative to control | Homo sapiens | 2 | ALA3621160 | protein format | Scientific Literature | |
4. | ALA3630865 | Binding | Inhibition of core catalytic domains of human PDE4 using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assay | Homo sapiens | 15 | ALA3627623 | protein format | Scientific Literature | |
5. | ALA3750621 | Binding | Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP | Homo sapiens | 16 | ALA3745619 | cell-based format | Scientific Literature | |
6. | ALA3750624 | Binding | Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis at 10 uM by HTRF assay in presence of dye d2 labelled cAMP | Homo sapiens | 1 | ALA3745619 | cell-based format | Scientific Literature | |
7. | ALA3772725 | Binding | Inhibition of PDE4 (unknown origin) | Homo sapiens | 17 | ALA3769307 | protein format | Scientific Literature | |
8. | ALA682878 | Functional | PDE4-related emetic activity in ferrets after intravenous administration at 10 mg/kg | Mustela putorius furo | 5 | ALA1133554 | organism-based format | Scientific Literature | |
9. | ALA684539 | Functional | Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophils | Cavia porcellus | 14 | ALA1131633 | assay format | Scientific Literature | |
10. | ALA685651 | Functional | In vivo ability to inhibit bronchospasm induced by intravenous doses of histamine on the artificially respired, anesthetized guinea pig | Oryctolagus cuniculus | 23 | ALA1126116 | organism-based format | Scientific Literature | |
11. | ALA819641 | Functional | Emetic effect in ferrets at peroral 10 mg/kg | Mustela putorius furo | 2 | ALA1132611 | organism-based format | Scientific Literature | |
12. | ALA819642 | Functional | Emetic effect in ferrets at peroral 100 mg/kg | Mustela putorius furo | 1 | ALA1132611 | organism-based format | Scientific Literature | |
13. | ALA819643 | Functional | Emetic effect in ferrets at peroral 30 mg/kg dose | Mustela putorius furo | 2 | ALA1132611 | organism-based format | Scientific Literature | |
14. | ALA819645 | Functional | Emetic effect in ferrets, plasma concentration | Mustela putorius furo | 8 | ALA1133688 | cell-free format | Scientific Literature | |
15. | ALA819646 | Functional | Emetic effect in ferrets, peroral mg/kg dose | Mustela putorius furo | 12 | ALA1133688 | organism-based format | Scientific Literature | |
16. | ALA819647 | Functional | Emetic effect in ferrets at peroral 100 mg/kg dose | Mustela putorius furo | 1 | ALA1132611 | organism-based format | Scientific Literature | |
17. | ALA819311 | Binding | Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE. | 18 | ALA1124643 | protein format | Scientific Literature | ||
18. | ALA819312 | Binding | Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE. | 11 | ALA1124643 | protein format | Scientific Literature | ||
19. | ALA819313 | Binding | Inhibition of cAMP-PDE phosphodiesterase from bovine aorta using 1 uM cAMP (insignificant) | Bos taurus | 3 | ALA1124643 | protein format | Scientific Literature | |
20. | ALA819317 | Binding | Inhibitory activity against c-AMP phosphodiesterase in guinea pig tracheal muscle. | Cavia porcellus | 8 | ALA1125335 | tissue-based format | Scientific Literature |