# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3423916 | Binding | Agonist activity at CXCR4 (unknown origin) at 12.5 uM relative to control | Homo sapiens | 1 | ALA3421577 | single protein format | Scientific Literature | |
2. | ALA3424055 | Binding | Antagonist activity at CXCR4 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA3421577 | single protein format | Scientific Literature | |
3. | ALA3583503 | Binding | Inhibition of [125I]SDF-1alpha binding to CXCR4 (unknown origin) expressed in HEK293 cell membranes incubated for 1 hr by radioligand displacement assay | Homo sapiens | 26 | ALA3580653 | cell-based format | Scientific Literature | |
4. | ALA3610413 | Binding | Inhibition of CXCR4 assessed as reduction in fusion of human HeLa/67 as target cells expressing CD4, CCR5, and CXCR4) and Lai envelope-expressing effector cells (CXCR4-tropic/CD4-dependent) | Homo sapiens | 1 | ALA3608277 | assay format | Scientific Literature | |
5. | ALA3610414 | Binding | Inhibition of CXCR4 assessed as reduction in fusion of human ACTOne-X4 cells as target cells expressing only CXCR4) with effector cells expressing HIV-8x envelope (CD4-independent requiring only CXCR4 and not CD4) | Homo sapiens | 1 | ALA3608277 | cell-based format | Scientific Literature | |
6. | ALA3610417 | Binding | Inhibition of CXCR4 in human Jurkat cells assessed as reduction in HIV-Nef-M1-induced mitochondrial membrane depolarization at 0.01 to 100 uM by JC1 dye based fluorescence depolarization assay | Homo sapiens | 4 | ALA3608277 | cell-based format | Scientific Literature | |
7. | ALA3610419 | Binding | Displacement of [125I]-SDF1 form CXCR4 (unknown origin) at 1 mM | Homo sapiens | 1 | ALA3608277 | single protein format | Scientific Literature | |
8. | ALA3610420 | Functional | Antagonist activity against CXCR4 (unknown origin) by Ca2+ flux GPCR signaling assay | Homo sapiens | 1 | ALA3608277 | single protein format | Scientific Literature | |
9. | ALA3630972 | Functional | Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of CXCL12-induced calcium flux | Homo sapiens | 15 | ALA3627700 | cell-based format | Scientific Literature | |
10. | ALA3630975 | Binding | Displacement of [125I]-SDF-1 from CXCR4 (unknown origin) | Homo sapiens | 2 | ALA3627700 | single protein format | Scientific Literature | |
11. | ALA3631598 | Binding | Displacement of fluorescently-labeled-TZ14011 from CXCR4 in human Jurkat cells incubated for 30 mins by fluorescence analysis | Homo sapiens | 2 | ALA3627622 | cell-based format | Scientific Literature | |
12. | ALA3631095 | Binding | Displacement of 125I-SDF-1 from human CXCR4 expressed in HEK293 cells incubated for 1.5 hrs by Topcount analysis | Homo sapiens | 2 | ALA3627649 | cell-based format | Scientific Literature | |
13. | ALA3782247 | Binding | Displacement of [125I]SDF-1 from human CXCR4 expressed in HEK293 cell membrane | Homo sapiens | 1 | ALA3779779 | cell-based format | Scientific Literature | |
14. | ALA3782470 | Binding | Antagonist activity at CXCR4 expressed in human U373-MAGI cells assessed as inhibition of HIV1 gp120-induced cell-cell fusion between HIV1 NL4-3 envelope expressing HEK293T cells to CXCR4 expressing human U373-MAGI cells incubated for 6 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA3779779 | cell-based format | Scientific Literature | |
15. | ALA3802805 | Functional | Antagonist activity against CXCR4 in in human MOLT4 cells assessed as inhibition of SDF1alpha -induced Ca2+ mobilization after 30 mins by FACS analysis | Homo sapiens | 1 | ALA3797033 | cell-based format | Scientific Literature | |
16. | ALA3829147 | Binding | Displacement of biotinylated TN14003 from CXCR4 CXCL12 binding domain in human MDA-MB-231 cells preincubated for 10 mins followed by biotinylated TN14003 addition measured after 30 mins using streptavidin-conjugated rhodamine by fluorescence microscopic analysis | Homo sapiens | 33 | ALA3826889 | cell-based format | Scientific Literature | |
17. | ALA3829150 | Binding | Potency index, ratio of AMD3100 EC to compound EC for displacement of biotinylated TN14003 from CXCR4 CXCL12 binding domain in human MDA-MB-231 cells | Homo sapiens | 2 | ALA3826889 | cell-based format | Scientific Literature | |
18. | ALA650909 | Binding | Inhibitory activity based on the inhibition of [Ca2+] mobilization induced by human SDF-1alpha stimulation through C-X-C chemokine receptor type 4 | 1 | ALA1135248 | single protein format | Scientific Literature | ||
19. | ALA650910 | Binding | Inhibitory activity based on the inhibition of [Ca2+] mobilization induced by human SDF-1alpha stimulation through C-X-C chemokine receptor type 4 | 1 | ALA1135248 | single protein format | Scientific Literature | ||
20. | ALA650911 | Binding | Binding affinity towards CXCR4 receptor | 1 | ALA1135101 | single protein format | Scientific Literature |