# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3637423 | Functional | Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FRET assay | Rattus norvegicus | 4 | ALA3632567 | cell-based format | Scientific Literature | |
2. | ALA3755700 | Functional | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 10 uM in presence of 3 mM extracellular Ca2+ by IP-one assay | Rattus norvegicus | 7 | ALA3751687 | cell-based format | Scientific Literature | |
3. | ALA3755701 | Functional | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 3 uM in presence of 3 mM extracellular Ca2+ by IP-one assay | Rattus norvegicus | 18 | ALA3751687 | cell-based format | Scientific Literature | |
4. | ALA3755702 | Functional | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 10 uM in presence of 2 mM extracellular Ca2+ by IP-one assay | Rattus norvegicus | 10 | ALA3751687 | cell-based format | Scientific Literature | |
5. | ALA3755703 | Functional | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 3 uM in presence of 2 mM extracellular Ca2+ by IP-one assay | Rattus norvegicus | 6 | ALA3751687 | cell-based format | Scientific Literature | |
6. | ALA3755704 | Functional | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 0.1 uM in presence of 3 mM extracellular Ca2+ by IP-one assay | Rattus norvegicus | 1 | ALA3751687 | cell-based format | Scientific Literature | |
7. | ALA3755705 | Functional | Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one assay | Rattus norvegicus | 6 | ALA3751687 | cell-based format | Scientific Literature | |
8. | ALA656307 | Functional | Compound was evaluated for accumulation of [3H]- IP in CHO (CaSR) cells expressing rat cloned calcium sensing receptor | 19 | ALA1133298 | cell-based format | Scientific Literature | ||
9. | ALA656308 | Functional | Maximal stimulation of [3H]-inositol phosphates production in CHO cells expressing rat Calcium sensing receptor (CaSR) at 10 mM [Ca2+] | 17 | ALA1147450 | cell-based format | Scientific Literature | ||
10. | ALA656309 | Functional | Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+] | 2 | ALA1147450 | cell-based format | Scientific Literature | ||
11. | ALA870549 | Functional | Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor | Rattus norvegicus | 3 | ALA1141245 | cell-based format | Scientific Literature | |
12. | ALA870363 | Functional | Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation at 10 uM | Rattus norvegicus | 31 | ALA1145339 | cell-based format | Scientific Literature | |
13. | ALA870365 | Functional | Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation at 1 uM | Rattus norvegicus | 23 | ALA1145339 | cell-based format | Scientific Literature | |
14. | ALA866784 | Functional | Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation | Rattus norvegicus | 8 | ALA1145339 | cell-based format | Scientific Literature | |
15. | ALA1785978 | Functional | Negative allosteric modulator activity at rat calcium sensing receptor expressed in HEK cells | Rattus norvegicus | 1 | ALA1781979 | cell-based format | Scientific Literature | |
16. | ALA1804306 | Functional | Agonist activity at rat CaSR expressed in CHO cells assessed as increase of calcium-induced inositol phosphate accumulation at 10 uM after 24 hrs by HTRF assay relative to calcium | Rattus norvegicus | 10 | ALA1800047 | cell-based format | Scientific Literature | |
17. | ALA4047176 | Functional | Agonist activity at rat CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay | Rattus norvegicus | 1 | ALA4043225 | cell-based format | Scientific Literature | |
18. | ALA4122630 | Functional | Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISA | Rattus norvegicus | 15 | ALA4118154 | cell-based format | Scientific Literature |