| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3509382 | ADME | Inhibition of CYP3A4/5 in human liver microsomes from 10 healthy donors at 10 uM aliskiren (SPP100) | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 2. | ALA3508969 | ADME | Estimated contribution of CYP3A4/5 to oxidative metabolism of [14C] aliskiren hemifumarate based on studies with microsomes from baculovirus-infected insect cells expressing recombinant human CYP450s and studies with pooled human liver microsomes from 22 donors | Homo sapiens | 1 | ALA3508693 | microsome format | FDA Approval Packages | |
| 3. | ALA1919560 | ADME | Inhibition of CYP3A4/5-mediated testosterone 6beta-hydroxylation in human liver microsomes by LCMS analysis | Homo sapiens | 1 | ALA1914447 | microsome format | Scientific Literature | |
| 4. | ALA1919561 | ADME | Inhibition of CYP3A4/5-mediated midazolam 1'-hydroxylation in human liver microsomes by LCMS analysis | Homo sapiens | 1 | ALA1914447 | microsome format | Scientific Literature | |
| 5. | ALA2043697 | ADME | Inhibition of CYP3A4/CYP3A5-mediated testosterone 6beta-hydroxylation in human liver microsomes | Homo sapiens | 2 | ALA2040800 | microsome format | Scientific Literature | |
| 6. | ALA2061440 | ADME | Inhibition of CYP3A4/5 in human liver microsomes | Homo sapiens | 12 | ALA2057177 | microsome format | Scientific Literature | |
| 7. | ALA2061441 | ADME | Inhibition of CYP3A4/6 in human liver microsomes at 20 uM | Homo sapiens | 2 | ALA2057177 | microsome format | Scientific Literature | |
| 8. | ALA2174394 | ADME | Drug metabolism in human liver microsomes assessed as decrease in CYP3A4/5-mediated (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-6,7-dihydrothieno[3,2-c]pyridin-5-ium formation at 20 uM in presence of ketoconazole | Homo sapiens | 1 | ALA2169782 | microsome format | Scientific Literature | |
| 9. | ALA2174395 | ADME | Drug metabolism in human liver microsomes assessed as CYP3A4/5-mediated (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-6,7-dihydrothieno[3,2-c]pyridin-5-ium formation at 50 uM | Homo sapiens | 1 | ALA2169782 | microsome format | Scientific Literature | |
| 10. | ALA2174396 | ADME | Drug metabolism in human liver microsomes assessed as CYP3A4/5-mediated (2S)-methyl 2-(2-chlorophenyl)-2-(3-hydroxy-2,3,6,7-tetrahydrothieno[3,2-c]pyridin-5(4H)-yl)acetate formation at 50 uM | Homo sapiens | 1 | ALA2169782 | microsome format | Scientific Literature | |
| 11. | ALA2174402 | ADME | Prodrug activation in human liver microsomes assessed as CYP3A4/5-mediated 2-oxo-clopidogrel formation at 50 uM | Homo sapiens | 1 | ALA2169782 | microsome format | Scientific Literature | |
| 12. | ALA2208570 | ADME | Inhibition of CYP3A4/5 in human liver microsomes at 100 uM | Homo sapiens | 1 | ALA2203122 | microsome format | Scientific Literature | |
| 13. | ALA2208571 | ADME | Induction of CYP3A4/5 in human liver microsomes at 100 uM | Homo sapiens | 1 | ALA2203122 | microsome format | Scientific Literature | |
| 14. | ALA2343820 | ADME | Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylation | Homo sapiens | 20 | ALA2331102 | microsome format | Scientific Literature | |
| 15. | ALA2339608 | ADME | Drug metabolism in human liver microsomes assessed as CYP3A4/5-mediated 2-Oxo-clopidogrel formation by LC-MS/MS analysis | Homo sapiens | 4 | ALA2331123 | microsome format | Scientific Literature | |
| 16. | ALA2390658 | ADME | Time-dependent inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate at 0.14 to 100 uM incubated for 30 mins prior to substrate addition | Homo sapiens | 8 | ALA2384944 | microsome format | Scientific Literature | |
| 17. | ALA2388954 | ADME | Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate addition measured after 10 mins | Homo sapiens | 8 | ALA2384944 | microsome format | Scientific Literature | |
| 18. | ALA2399576 | ADME | Inhibition of CYP3A4/5 in human intestinal microsomes using midazolam as substrate after 4 mins | Homo sapiens | 15 | ALA2396584 | microsome format | Scientific Literature | |
| 19. | ALA4122664 | ADME | Inhibition of CYP3A4/5 (unknown origin) | Homo sapiens | 1 | ALA4118154 | protein format | Scientific Literature | |
| 20. | ALA4406417 | ADME | Inhibition of CYP3A4/5 in human pooled liver microsomes using midazolam as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | ALA4402606 | microsome format | Scientific Literature |
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