# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2043697 | A | Inhibition of CYP3A4/CYP3A5-mediated testosterone 6beta-hydroxylation in human liver microsomes | Homo sapiens | 2 | microsome format | Scientific Literature | ||
2. | ALA2061440 | A | Inhibition of CYP3A4/5 in human liver microsomes | Homo sapiens | 12 | microsome format | Scientific Literature | ||
3. | ALA2061441 | A | Inhibition of CYP3A4/6 in human liver microsomes at 20 uM | Homo sapiens | 2 | microsome format | Scientific Literature | ||
4. | ALA1919560 | A | Inhibition of CYP3A4/5-mediated testosterone 6beta-hydroxylation in human liver microsomes by LCMS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
5. | ALA1919561 | A | Inhibition of CYP3A4/5-mediated midazolam 1'-hydroxylation in human liver microsomes by LCMS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
6. | ALA2174394 | A | Drug metabolism in human liver microsomes assessed as decrease in CYP3A4/5-mediated (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-6,7-dihydrothieno[3,2-c]pyridin-5-ium formation at 20 uM in presence of ketoconazole | Homo sapiens | 1 | microsome format | Scientific Literature | ||
7. | ALA2174395 | A | Drug metabolism in human liver microsomes assessed as CYP3A4/5-mediated (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-6,7-dihydrothieno[3,2-c]pyridin-5-ium formation at 50 uM | Homo sapiens | 1 | microsome format | Scientific Literature | ||
8. | ALA2174396 | A | Drug metabolism in human liver microsomes assessed as CYP3A4/5-mediated (2S)-methyl 2-(2-chlorophenyl)-2-(3-hydroxy-2,3,6,7-tetrahydrothieno[3,2-c]pyridin-5(4H)-yl)acetate formation at 50 uM | Homo sapiens | 1 | microsome format | Scientific Literature | ||
9. | ALA2174402 | A | Prodrug activation in human liver microsomes assessed as CYP3A4/5-mediated 2-oxo-clopidogrel formation at 50 uM | Homo sapiens | 1 | microsome format | Scientific Literature | ||
10. | ALA2208570 | A | Inhibition of CYP3A4/5 in human liver microsomes at 100 uM | Homo sapiens | 1 | microsome format | Scientific Literature | ||
11. | ALA2208571 | A | Induction of CYP3A4/5 in human liver microsomes at 100 uM | Homo sapiens | 1 | microsome format | Scientific Literature | ||
12. | ALA2343820 | A | Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylation | Homo sapiens | 20 | microsome format | Scientific Literature | ||
13. | ALA2339608 | A | Drug metabolism in human liver microsomes assessed as CYP3A4/5-mediated 2-Oxo-clopidogrel formation by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
14. | ALA2390658 | A | Time-dependent inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate at 0.14 to 100 uM incubated for 30 mins prior to substrate addition | Homo sapiens | 8 | microsome format | Scientific Literature | ||
15. | ALA2388954 | A | Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate addition measured after 10 mins | Homo sapiens | 8 | microsome format | Scientific Literature | ||
16. | ALA2399576 | A | Inhibition of CYP3A4/5 in human intestinal microsomes using midazolam as substrate after 4 mins | Homo sapiens | 15 | microsome format | Scientific Literature | ||
17. | ALA3509382 | A | Inhibition of CYP3A4/5 in human liver microsomes from 10 healthy donors at 10 uM aliskiren (SPP100) | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
18. | ALA3508969 | A | Estimated contribution of CYP3A4/5 to oxidative metabolism of [14C] aliskiren hemifumarate based on studies with microsomes from baculovirus-infected insect cells expressing recombinant human CYP450s and studies with pooled human liver microsomes from 22 donors | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
19. | ALA4122664 | A | Inhibition of CYP3A4/5 (unknown origin) | Homo sapiens | 1 | protein format | Scientific Literature | ||
20. | ALA4406417 | A | Inhibition of CYP3A4/5 in human pooled liver microsomes using midazolam as substrate after 10 mins by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature |