| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3744488 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as decrease in TNF-alpha-induced GROalpha mRNA level pretreated with compound for 30 mins followed by addition of TNF-alpha measured after 12 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 2. | ALA3744689 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as decrease in TNF-alpha-induced GROalpha mRNA level pretreated with compound for 30 mins followed by addition of TNF-alpha measured after 12 hrs by QR-PCR analysis | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 3. | ALA3744690 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as decrease in TNF-alpha-induced GROalpha mRNA level at 10 uM pretreated for 30 mins followed by addition of TNF-alpha measured after 12 hrs by QR-PCR analysis | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 4. | ALA3744691 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as inhibition of TNF-alpha-induced GROalpha promoter activation pretreated with compound for 30 mins followed by addition of TNF-alpha for 8 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 5. | ALA3744694 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as inhibition of TNF-alpha-induced IkappaB phosphorylation at Ser-32 residue at 5 and 10 uM pretreated for 30 mins followed by addition of TNF-alpha for 1 hr by immunoblot analysis | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 6. | ALA3744695 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as inhibition of TNF-alpha-induced p65/RelA phosphorylation at Ser-536 residue at 5 and 10 uM pretreated for 30 mins followed by addition of TNF-alpha for 1 hr by immunoblot analysis | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 7. | ALA3744696 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as inhibition of TNF-alpha-induced p65/RelA phosphorylation at Ser-536 residue in nucleus at 10 uM pretreated for 30 mins followed by addition of TNF-alpha for 1 hr by immunofluorescence analysis | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 8. | ALA3744697 | Binding | Inhibition of IKK in human MDA-MB-231 cells assessed as inhibition of TNF-alpha-induced NF-kappaB transcriptional activity pretreated with compound for 30 mins followed by addition of TNF-alpha for 8 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA3739305 | cell-based format | Scientific Literature | |
| 9. | ALA872205 | Binding | Inhibitory concentration against IKK | 1 | ALA1141103 | protein complex format | Scientific Literature | ||
| 10. | ALA884481 | Functional | Inhibitory activity against IKK | Homo sapiens | 1 | ALA1140394 | assay format | Scientific Literature | |
| 11. | ALA861784 | Binding | Inhibitory activity against IKK complex isolated from HeLa cells | Homo sapiens | 20 | ALA1147757 | cell-based format | Scientific Literature | |
| 12. | ALA862759 | Functional | Inhibition of TNF-alpha-stimulated IkappaBalpha degradation | Homo sapiens | 8 | ALA1147757 | assay format | Scientific Literature | |
| 13. | ALA862760 | Functional | Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cells | Homo sapiens | 8 | ALA1147757 | cell-based format | Scientific Literature | |
| 14. | ALA862761 | Functional | Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cells | Homo sapiens | 8 | ALA1147757 | cell-based format | Scientific Literature | |
| 15. | ALA862762 | Functional | Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cells | Homo sapiens | 8 | ALA1147757 | cell-based format | Scientific Literature | |
| 16. | ALA871358 | Functional | Inhibition of LPS-induced TNFalpha release from human PBMC | Homo sapiens | 1 | ALA1147757 | assay format | Scientific Literature | |
| 17. | ALA866831 | Binding | Inhibition of IKK | Homo sapiens | 1 | ALA1138058 | protein complex format | Scientific Literature | |
| 18. | ALA913894 | Binding | Inhibition of IKK | Homo sapiens | 1 | ALA1149291 | protein complex format | Scientific Literature | |
| 19. | ALA920656 | Binding | Inhibition of IKK | Homo sapiens | 1 | ALA1144565 | protein complex format | Scientific Literature | |
| 20. | ALA900106 | Binding | Inhibition of IKK | Homo sapiens | 1 | ALA1138235 | protein complex format | Scientific Literature |
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