# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA811117 | B | The cGMP produced by compound was expressed as a ratio between the percentage of the DEA/NO response for the compound | 1 | protein complex format | Scientific Literature | |||
2. | ALA811118 | B | IGC activation was determined in the presence of [alpha-32P]GTP at a concentration of 82 uM | 1 | protein complex format | Scientific Literature | |||
3. | ALA811119 | B | sGC activation was determined in the presence of [alpha-32P]GTP at a concentration of 82 uM | 9 | protein complex format | Scientific Literature | |||
4. | ALA869997 | F | Ratio of activation of sGC by compound over that of control, in presence of carbon monooxide (basal activity 33+/-3 nmol/min/mg in absence of CO) | 5 | assay format | Scientific Literature | |||
5. | ALA867095 | F | Ratio of activation of sGC by compound over that of control, in absence of carbon monooxide (basal activity 33+/-3 nmol/min/mg) | 5 | assay format | Scientific Literature | |||
6. | ALA867097 | F | Effect on YC-1 mediated activation of sGC in presence of carbon monoxide | 1 | assay format | Scientific Literature | |||
7. | ALA865676 | F | Effect on cGMP production in porcine iris-ciliary body at 10 uM | Sus scrofa | 6 | assay format | Scientific Literature | ||
8. | ALA865677 | F | Effect on cGMP production in porcine iris-ciliary body at 100 uM | Sus scrofa | 6 | assay format | Scientific Literature | ||
9. | ALA869051 | B | Inhibition of rat lung sGC | Rattus norvegicus | 6 | protein complex format | Scientific Literature | ||
10. | ALA862867 | B | Inhibition of stimulated guanylate cyclase at 1 uM | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
11. | ALA1918701 | B | Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by LC-MS enzyme assay | Homo sapiens | 16 | protein complex format | Scientific Literature | ||
12. | ALA1918702 | B | Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by FP assay | Homo sapiens | 10 | protein complex format | Scientific Literature | ||
13. | ALA3881285 | B | Activation of sGC (unknown origin) assessed as cGMP formation using GTP as substrate by Catch-point cGMP assay relative to DMSO | Homo sapiens | 24 | protein complex format | Patent Bioactivity Data | ||
14. | ALA3223739 | B | Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin in presence of cysteine | Homo sapiens | 8 | protein complex format | Scientific Literature | ||
15. | ALA3223740 | B | Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin in presence of cysteine relative to GTN | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
16. | ALA3223741 | B | Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
17. | ALA3595122 | B | Activation of sGC in human hCMEC/D3 cells assessed as production of cGMP per million cells using [3H]-cGMP after 1 hr by liquid scintillation counting | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
18. | ALA3608014 | B | Binding affinity to human recombinant sGC catalytic subunit by surface plasmon resonance analysis | Homo sapiens | 17 | protein complex format | Scientific Literature | ||
19. | ALA3608023 | B | Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 1 uM sGC activator cinaciguat | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
20. | ALA3608024 | B | Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 20 nM sGC activator cinaciguat | Homo sapiens | 1 | protein complex format | Scientific Literature |