# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA811117 | B | The cGMP produced by compound was expressed as a ratio between the percentage of the DEA/NO response for the compound | 1 | ALA1134419 | protein complex format | Scientific Literature | ||
2. | ALA811118 | B | IGC activation was determined in the presence of [alpha-32P]GTP at a concentration of 82 uM | 1 | ALA1134782 | protein complex format | Scientific Literature | ||
3. | ALA811119 | B | sGC activation was determined in the presence of [alpha-32P]GTP at a concentration of 82 uM | 9 | ALA1134782 | protein complex format | Scientific Literature | ||
4. | ALA869997 | F | Ratio of activation of sGC by compound over that of control, in presence of carbon monooxide (basal activity 33+/-3 nmol/min/mg in absence of CO) | 5 | ALA1138113 | assay format | Scientific Literature | ||
5. | ALA867095 | F | Ratio of activation of sGC by compound over that of control, in absence of carbon monooxide (basal activity 33+/-3 nmol/min/mg) | 5 | ALA1138113 | assay format | Scientific Literature | ||
6. | ALA867097 | F | Effect on YC-1 mediated activation of sGC in presence of carbon monoxide | 1 | ALA1138113 | assay format | Scientific Literature | ||
7. | ALA865676 | F | Effect on cGMP production in porcine iris-ciliary body at 10 uM | Sus scrofa | 6 | ALA1146947 | assay format | Scientific Literature | |
8. | ALA865677 | F | Effect on cGMP production in porcine iris-ciliary body at 100 uM | Sus scrofa | 6 | ALA1146947 | assay format | Scientific Literature | |
9. | ALA869051 | B | Inhibition of rat lung sGC | Rattus norvegicus | 6 | ALA1138063 | protein complex format | Scientific Literature | |
10. | ALA862867 | B | Inhibition of stimulated guanylate cyclase at 1 uM | Homo sapiens | 1 | ALA1138064 | protein complex format | Scientific Literature | |
11. | ALA1918701 | B | Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by LC-MS enzyme assay | Homo sapiens | 16 | ALA1914314 | protein complex format | Scientific Literature | |
12. | ALA1918702 | B | Activation of human soluble guanylate cyclase assessed as production of cGMP in presence of nitric oxide donor, SIN-1 by FP assay | Homo sapiens | 10 | ALA1914314 | protein complex format | Scientific Literature | |
13. | ALA3223739 | B | Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin in presence of cysteine | Homo sapiens | 8 | ALA3217567 | protein complex format | Scientific Literature | |
14. | ALA3223740 | B | Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin in presence of cysteine relative to GTN | Homo sapiens | 1 | ALA3217567 | protein complex format | Scientific Literature | |
15. | ALA3223741 | B | Activation of soluble guanylate cyclase (unknown origin) assessed as apparent initial rate of oxidation of oxyhemoglobin | Homo sapiens | 1 | ALA3217567 | protein complex format | Scientific Literature | |
16. | ALA3595122 | B | Activation of sGC in human hCMEC/D3 cells assessed as production of cGMP per million cells using [3H]-cGMP after 1 hr by liquid scintillation counting | Homo sapiens | 9 | ALA3593200 | cell-based format | Scientific Literature | |
17. | ALA3608014 | B | Binding affinity to human recombinant sGC catalytic subunit by surface plasmon resonance analysis | Homo sapiens | 17 | ALA3603751 | protein complex format | Scientific Literature | |
18. | ALA3608023 | B | Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 1 uM sGC activator cinaciguat | Homo sapiens | 1 | ALA3603751 | protein complex format | Scientific Literature | |
19. | ALA3608024 | B | Inhibition of sGC (unknown origin) assessed as inhibition of cGMP production in presence of 20 nM sGC activator cinaciguat | Homo sapiens | 1 | ALA3603751 | protein complex format | Scientific Literature | |
20. | ALA3608030 | B | Binding affinity to full length human recombinant sGC by surface plasmon resonance analysis | Homo sapiens | 1 | ALA3603751 | protein complex format | Scientific Literature |