| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2114880 | F | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS): Hit Confirmation. (Class of assay: confirmatory) | Homo sapiens | 19 | ALA1201862 | assay format | PubChem BioAssays | |
| 2. | ALA2114738 | F | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | Homo sapiens | 15,494 | ALA1201862 | assay format | PubChem BioAssays | |
| 3. | ALA2156343 | B | Inhibition of glutaminase kidney isoform at 10 uM | 1 | ALA2150994 | single protein format | Scientific Literature | ||
| 4. | ALA2189066 | B | Uncompetitive inhibition of human kidney glutaminase (124 to 669) assessed as reduction of glutamine hydrolysis by double-reciprocal plot analysis | Homo sapiens | 1 | ALA2177047 | single protein format | Scientific Literature | |
| 5. | ALA2189067 | B | Inhibition of human kidney glutaminase (124 to 669) using L-[3H]-glutamine as substrate after 45 mins by GLS assay | Homo sapiens | 27 | ALA2177047 | single protein format | Scientific Literature | |
| 6. | ALA3705630 | B | Enzyme Assay-Time Dependence: Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH. | Homo sapiens | 326 | ALA3639086 | single protein format | BindingDB Database | |
| 7. | ALA3705631 | B | Enzyme Assay: Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH. | Homo sapiens | 362 | ALA3639086 | single protein format | BindingDB Database | |
| 8. | ALA3773708 | B | Inhibition of recombinant HIs-tagged human GAC (residue 72-603 aa) expressed in Escherichia coli after 10 mins using glutamine as substrate | Homo sapiens | 33 | ALA3769321 | assay format | Scientific Literature | |
| 9. | ALA3811869 | B | Inhibition of 6His-tagged GLS1 (63-669 residues) (unknown origin) expressed in Escherichia coli using glutamine as substrate after 15 mins by Glutamate Oxidase/ AmplexRed coupled assay | Homo sapiens | 6 | ALA3808343 | assay format | Scientific Literature | |
| 10. | ALA3811870 | B | Inhibition of GLS1 in human PC3 cells assessed as cellular glutamate depletion levels after 6 hrs by Glutamate Oxidase/ AmplexRed coupled assay | Homo sapiens | 6 | ALA3808343 | cell-based format | Scientific Literature | |
| 11. | ALA3816484 | B | Inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate after 45 mins by topcount method | Homo sapiens | 22 | ALA3813656 | single protein format | Scientific Literature | |
| 12. | ALA3816485 | B | Time-dependent inhibition of human kidney type glutaminase (124 to 669 residues) using L-[3H]-glutamine as substrate by topcount method | Homo sapiens | 2 | ALA3813656 | single protein format | Scientific Literature | |
| 13. | ALA3997301 | B | Inhibition of recombinant KGA (unknown origin) using glutamine as substrate | Homo sapiens | 8 | ALA3994651 | single protein format | Scientific Literature | |
| 14. | ALA3997302 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Vmax of glutamine consumption at 2.5 uM by Lineweaver-Burk plot analysis (Rvb = 0.06744 OD/min) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature | |
| 15. | ALA3997303 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Km for glutamine consumption at 2.5 uM by Lineweaver-Burk plot analysis (Rvb = 2.198 mM) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature | |
| 16. | ALA3997304 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Vmax of glutamine consumption at 5 uM by Lineweaver-Burk plot analysis (Rvb = 0.06744 OD/min) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature | |
| 17. | ALA3997305 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Km for glutamine consumption at 5 uM by Lineweaver-Burk plot analysis (Rvb = 2.198 mM) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature | |
| 18. | ALA3997306 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Vmax of glutamine consumption at 10 uM by Lineweaver-Burk plot analysis (Rvb = 0.06744 OD/min) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature | |
| 19. | ALA3997307 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Km for glutamine consumption at 10 uM by Lineweaver-Burk plot analysis (Rvb = 2.198 mM) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature | |
| 20. | ALA3997308 | B | Non-competitive inhibition of recombinant KGA (unknown origin) assessed as Vmax of glutamine consumption at 20 uM by Lineweaver-Burk plot analysis (Rvb = 0.06744 OD/min) | Homo sapiens | 1 | ALA3994651 | single protein format | Scientific Literature |
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