| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2161819 | B | Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated mouse Ptpn22+/+ T cells assessed as increase in Src Y416 phosphorylation at 50 uM by Western blotting relative to untreated control | Mus musculus | 28 | ALA2157931 | cell-based format | Scientific Literature | |
| 2. | ALA2161824 | B | Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD8+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 50 uM incubated for 24 hrs (Rvb = 5.3%) | Mus musculus | 1 | ALA2157931 | assay format | Scientific Literature | |
| 3. | ALA2161825 | B | Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD4+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 100 uM incubated for 24 hrs (Rvb = 29.2%) | Mus musculus | 1 | ALA2157931 | assay format | Scientific Literature | |
| 4. | ALA2161831 | B | Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD4+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 50 uM incubated for 24 hrs (Rvb = 29.2%) | Mus musculus | 1 | ALA2157931 | assay format | Scientific Literature | |
| 5. | ALA2161833 | B | Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated mouse Ptpn22+/+ T cells assessed as increase in Lck Y394 dephosphorylation at 50 uM by Western blotting | Mus musculus | 1 | ALA2157931 | cell-based format | Scientific Literature | |
| 6. | ALA2161841 | B | Inhibition of LYP in anti-CD3 and antiCD28 antibody-stimulated C57BL/6 mouse CD8+ splenocytes assessed as increase in TCR signaling-stimulated CD69 expression at 100 uM incubated for 24 hrs (Rvb = 5.3%) | Mus musculus | 1 | ALA2157931 | assay format | Scientific Literature | |
| 7. | ALA2400638 | B | Inhibition of PEP in C57BL/6 mouse BMMC assessed as reduction in anti-DNP-IgE-induced degranulation by measuring beta-hexosaminidase release at 5 to 20 uM after 1 hr by spectrophotometric analysis | Mus musculus | 1 | ALA2396532 | single protein format | Scientific Literature | |
| 8. | ALA2400639 | B | Inhibition of PEP in mouse CD4 and CD8 double positive thymocytes assessed as increase in Nur77 expression at 15 uM after 3.5 hrs by GFP-based FACS analysis | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 9. | ALA2400640 | B | Inhibition of PEP in mouse CD4 and CD8 double positive thymocytes assessed as increase in CD69 expression at 15 uM after 3.5 hrs by FACS analysis | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 10. | ALA2401203 | B | Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in NFAT expression after 1 hr by luciferase reporter gene assay | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 11. | ALA2401205 | B | Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in anti-DNP-IgE-induced NFAT expression after 1 hr by luciferase reporter gene assay | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 12. | ALA2401206 | B | Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in anti-DNP-IgE-induced NFAT expression at 5 uM after 1 hr by luciferase reporter gene assay | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 13. | ALA2401215 | B | Inhibition of PEP in C57BL/6 mouse BMMC assessed as decrease in anti-DNP-IgE-induced NFAT expression at 20 uM after 1 hr by luciferase reporter gene assay | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!