| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2166659 | B | Activity of human SIRT6 assessed as decrotonylation of compound at 50 uM after 1 hr by trypsin developer-based fluorescence assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 2. | ALA2166868 | B | Activity of human SIRT6 assessed as deacylation of compound at 50 uM after 1 hr by trypsin developer-based fluorescence assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 3. | ALA2211908 | B | Inhibition of human recombinant SIRT6 assessed as 7-amino-4-methylcoumarin labelled Arg-His-Lys-Lys(epsilon-acetyl) substrate deacetylation after 90 mins by Fluor-de-Lys assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA2211909 | B | Inhibition of human recombinant SIRT6 assessed as 7-amino-4-methylcoumarin labelled Arg-His-Lys-Lys(epsilon-acetyl) substrate deacetylation at 200 uM after 90 mins by Fluor-de-Lys assay | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 5. | ALA2211912 | B | Inhibition of N-terminal His-tagged human recombinant SIRT6 (13 to 308) expressed in Escherichia coli Rosetta2 cells assessed as FdL-1 peptide substrate deacetylation at 100 uM after 45 mins by Fluor-de-Lys assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA3295496 | B | Inhibition of SIRT6 (unknown origin) at 200 uM by fluorescence-based assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 7. | ALA3295497 | B | Inhibition of SIRT6 (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA3295502 | B | Inhibition of SIRT6 in human BxPC3 cells assessed as increase in H3K9 acetylation at 100 uM after 18 hrs by immunoblot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA3295503 | B | Inhibition of SIRT6 in human BxPC3 cells assessed as increase in H3K9 acetylation at 100 uM after >18 hrs by immunoblot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA3418046 | B | Activity of SIRT6 (unknown origin) assessed as enzyme-mediated compound hydrolysis by measuring increase in fluorescence incubated for 60 mins in presence of NAD by HPLC method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3418047 | B | Activity of SIRT6 (unknown origin) assessed as enzyme-mediated compound hydrolysis by measuring increase in fluorescence incubated for 5 mins in presence of NAD by HPLC method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3418048 | B | Activity of SIRT6 (unknown origin) assessed as enzyme-mediated compound hydrolysis by measuring Kcat/Km ratio incubated for 60 mins in presence of NAD by HPLC method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3418049 | B | Activity of SIRT6 (unknown origin) assessed as enzyme-mediated compound hydrolysis by measuring Kcat/Km ratio incubated for 5 mins in presence of NAD by HPLC method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3418050 | B | Activity of SIRT6 (unknown origin) assessed as enzyme-mediated compound hydrolysis at 10 uM incubated for 60 mins in presence of NAD followed by 1 hr incubation with trypsin | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3418051 | B | Inhibition of SIRT6 (unknown origin) at 300 uM using (DABCYL)ISGASE(MyK)DIVHSE(EDANS)G substrate in presence of NAD followed by 1 hr incubation with trypsin by FRET assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA3418053 | B | Inhibition of SIRT6 (unknown origin) using (DABCYL)ISGASE(MyK)DIVHSE(EDANS)G substrate in presence of NAD followed by 1 hr incubation with trypsin by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3418054 | B | Inhibition of SIRT6 (unknown origin) using AMC containing peptide substructure by fluorogenic assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3603107 | B | Inhibition of human SIRT6 using H2N-EALPK-(Nepsilon-myristoyl-lysine)-TGGPQ-CONH2 as substrate after 12 mins by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3610053 | B | Inhibition of human GST-tagged SIRT6 after 12 mins by HPLC analysis in presence of beta-NAD | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3625951 | B | Inhibition of SIRT6 in human BxPC-3 cells assessed as increase in H3K9 acetylation by immunoblotting assay relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature |
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