# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579100 | Binding | Binding affinity to human CCR1 at 1 uM | Homo sapiens | 4 | ALA3576859 | single protein format | Scientific Literature | |
2. | ALA3616208 | Binding | Binding affinity to human CCR1 receptor assessed as inhibition of control specific binding at 10 uM | Homo sapiens | 1 | ALA3612012 | single protein format | Scientific Literature | |
3. | ALA3705351 | Binding | Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA). | Homo sapiens | 23 | ALA3638620 | single protein format | BindingDB Database | |
4. | ALA3706150 | Binding | Binding Assay: For radioligand competition studies, a final concentration of 1x105 THP-1 monocytic leukemia cells are combined with 100 μg of LS WGA PS beads (Amersham, Cat.#: RPNQ 0260) in 40 μL of assay buffer (RPMI 1640 without phenol red, 50 mM HEPES, 5 mM MgCl2, 1 mM CaCl2, 0.1% BSA). The THP-1 cell/bead mixture was added to each well of a 384-well assay plate (PerkinElmer, Cat. #:6007899) containing test compound in 3-fold serial dilution, with final concentrations ranging from 8 μM to 0.14 nM. A final concentration of 0.1 nM [125I]-MIP-1α (PerkinElmer, Cat. #NEX298) in 20 μL assay buffer was added to the reaction. Unlabeled MIP-1α was added in excess to some wells to determine non-specific binding. Sealed assay plates were incubated at room temperature for 12 h then analyzed by LEADseeker. | Homo sapiens | 5 | ALA3638549 | cell-based format | BindingDB Database | |
5. | ALA3744799 | Binding | Inhibition of human CCR1 at 10 uM by radioligand binding assay | Homo sapiens | 1 | ALA3739255 | single protein format | Scientific Literature | |
6. | ALA3778204 | Binding | Displacement of [125I]MIP-1alpha from human recombinant CCR1 receptor expressed in HEK293 cells at 10'-5 M | Homo sapiens | 2 | ALA3774372 | cell-based format | Scientific Literature | |
7. | ALA651916 | Binding | Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells | Homo sapiens | 9 | ALA1134433 | cell-based format | Scientific Literature | |
8. | ALA651917 | Functional | Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants | Homo sapiens | 8 | ALA1134764 | assay format | Scientific Literature | |
9. | ALA651918 | Functional | Compound was evaluated for the inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants; NT: not tested | Homo sapiens | 6 | ALA1134764 | assay format | Scientific Literature | |
10. | ALA651919 | Functional | Compound was evaluated for the inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants; NA: not active | Homo sapiens | 1 | ALA1134764 | assay format | Scientific Literature | |
11. | ALA651920 | Functional | Compound was evaluated for the inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants; NT: not tested | Homo sapiens | 1 | ALA1134764 | assay format | Scientific Literature | |
12. | ALA650697 | Binding | Binding affinity towards C-C chemokine receptor type 1 | 1 | ALA1146631 | single protein format | Scientific Literature | ||
13. | ALA650849 | Binding | Inhibitory effect on the binding of [125I]RANTES to C-C chemokine receptor type 1-expressing CHO cells | 1 | ALA1133188 | cell-based format | Scientific Literature | ||
14. | ALA650850 | Binding | Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells at 10 uM concentration | 11 | ALA1132282 | cell-based format | Scientific Literature | ||
15. | ALA650851 | Binding | Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells at 3 uM concentration | 4 | ALA1132282 | cell-based format | Scientific Literature | ||
16. | ALA651702 | Binding | Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells | 73 | ALA1132282 | cell-based format | Scientific Literature | ||
17. | ALA651703 | Binding | Binding affinity towards CCR1 receptor | 1 | ALA1135101 | single protein format | Scientific Literature | ||
18. | ALA651704 | Binding | Inhibitory activity against C-C chemokine receptor type 1 | 7 | ALA1133866 | single protein format | Scientific Literature | ||
19. | ALA651705 | Binding | Compound was evaluated for inhibitory activity against C-C chemokine receptor type 1 | 6 | ALA1133867 | single protein format | Scientific Literature | ||
20. | ALA651706 | Binding | The compound was tested for inhibition of Chemokine (MCP-3) binding against C-C chemokine receptor type 1 transfected in HEK 293 cells | 1 | ALA1131251 | cell-based format | Scientific Literature |