# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA702365 | F | Effect on resting membrane potential in SH-SY5Y human neuroblastoma cells expressing native KCNQ channels | Homo sapiens | 1 | assay format | Scientific Literature | ||
2. | ALA2050726 | F | Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction by liquid scintillation counting | 51 | cell-based format | Scientific Literature | |||
3. | ALA2150655 | B | Activation of KCNQ2/Q3 | 3 | protein complex format | Scientific Literature | |||
4. | ALA1070909 | B | Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay | 30 | cell-based format | Scientific Literature | |||
5. | ALA1272913 | B | Inhibition of KCNQ2/Q3 | 2 | protein complex format | Scientific Literature | |||
6. | ALA1693395 | B | Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay | 19 | cell-based format | Scientific Literature | |||
7. | ALA1693397 | B | Activation of human KCNQ2/Q3 expressed in CHO cells assessed as increase in channel current at -40 mV holding potential at 10 uM by whole cell patch-clamp assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
8. | ALA1693398 | B | Activation of human KCNQ2/Q3 expressed in CHO cells assessed as increase in channel current at -40 mV holding potential at 100 uM by whole cell patch-clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA1693503 | B | Activation of human KCNQ2/Q3 expressed in CHO cells held at -80 mV for 800 ms followed by depolarized to -40 mV for 800 ms followed by 800 ms pulse-back to 800 mV assessed as increase in both activation and deactivation tail current at 100 uM by whole cell patch-clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA1693504 | B | Activation of human KCNQ2/Q3 expressed in CHO cells held at -80 mV for 800 ms followed by depolarized to -40 mV for 800 ms followed by 800 ms pulse-back to 800 mV assessed as increase in both activation and deactivation tail current at 10 uM by whole cell patch-clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA1693507 | B | Activation of KCNQ2/Q3 expressed in CHO cells at 100 uM by atomic absorption Rb'+ efflux assay | 7 | cell-based format | Scientific Literature | |||
12. | ALA2169527 | F | Antagonist activity at KCNQ2/Q3 expressed in CHO cells incubated for 3 mins by automated patch clamp assay | 1 | cell-based format | Scientific Literature | |||
13. | ALA2328836 | B | Modulation of human KCNQ2/3 channel expressed in CHO-K1 cells by fluorescence assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
14. | ALA2328837 | B | Modulation of human KCNQ2/3 channel expressed in CHO-K1 cells by fluorescence assay relative to retigabine | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
15. | ALA3624288 | B | Activation of human Kv7.2/7.3 expressed in CHOK1 cells | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
16. | ALA3624290 | B | Activation of human Kv7.2/7.3 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4036811 | B | Activation of KCNQ2/3 (unknown origin) | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
18. | ALA4181784 | B | Inhibition of human Kv7.2/7.3 at 10 uM by patch clamp method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
19. | ALA4260479 | B | Activation of human Kv7.2/7.3 by patch clamp method | Homo sapiens | 15 | assay format | Scientific Literature | ||
20. | ALA4260480 | B | Activation of human Kv7.2/7.3 by patch clamp method relative to ML213 | Homo sapiens | 13 | assay format | Scientific Literature |