| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2328027 | B | Antagonist activity at CCR10 (unknown origin) assessed as inhibition of chemotaxis at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA2328619 | F | Antagonist activity at CCR10 (unknown origin) assessed as inhibition of calcium flux at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA2328641 | B | Binding affinity to CCR10 (unknown origin) at 10 uM by radioligand displacement assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA2330024 | F | Antagonist activity at CCR10 receptor (unknown origin) by [35S]GTPgammaS binding assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA3734215 | F | Antagonist activity against human CCR10 expressed in human KJMGER8 cells assessed as inhibition of human recombinant CTACK-induced increase in intracellular calcium level at 100 nmol/L pre-incubated for 30 mins before human recombinant CTACK stimulation for 5 mins by FLIPR assay | Homo sapiens | 82 | cell-based format | Patent Bioactivity Data | ||
| 6. | ALA3863299 | F | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flux in presence of coelenterazine H by chemiluminescence assay | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 7. | ALA3863300 | B | Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxis | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 8. | ALA3863302 | F | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in presence of coelenterazine H by FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA3863303 | B | Displacement of human CCL27-Fc from CCR10 expressed in HEK cell membranes by immunochemical binding analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3863304 | F | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by FLIPR assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA3863305 | F | Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flux by chemiluminescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA3863306 | F | Antagonist activity at human CCR10 expressed in HEK cells assessed as inhibition of human CCL27-dependent cAMP production | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA3863309 | B | Antagonist activity at human CCR10 expressed in HEK cell membranes assessed as inhibition of human CCL27-dependent europium-labeled GTP binding | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA3863353 | B | Reversible inhibition of human CCL27-Fc binding to CCR10 expressed in HEK cell membranes by immunochemical binding assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4028341 | F | Antagonist activity at human CCR10 expressed in CHOK1 cells assessed as inhibition of CCL27-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4145419 | F | Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment at 10 uM pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4145424 | F | Antagonist activity at human CCR10 expressed in human U2OS cells assessed as inhibition of CCL27-induced beta-arrestin recruitment pre-incubated for 30 mins before CCL27 stimulation for 90 or 180 mins by chemiluminescence method | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 18. | ALA4145429 | F | Antagonist activity at CCR10 in human MDA-MB-231 cells assessed as inhibition of CCL27-induced proliferation up to 10 uM preincubated for 2 hrs followed by CCL27 addition measured after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4145430 | F | Antagonist activity at CCR10 in human MDA-MB-231 cells assessed as inhibition of CCL27-induced proliferation preincubated for 2 hrs followed by CCL27 addition measured after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4630467 | B | Antagonist activity at human Gi/G0-coupled CCR10 receptor expressed in human U2OS cells assessed as inhibition of CCL27-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CCL27 stimulation and measured after 90 to 180 mins by pathhunter assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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