# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2352787 | B | Inhibition of PCNA in human U2OS cells assessed as cisplatin-induced DNA damage at 25 uM after 22 hrs by comet assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA2352789 | B | Inhibition of PCNA in human HeLa cells assessed as increase in histone H2AX phosphorylation at 10 uM after 18 hrs by flow cytometric analysis in absence of cisplatin | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
3. | ALA2352790 | B | Inhibition of PCNA in human cisplatin-damaged HeLa cells assessed as increase in histone H2AX phosphorylation at 10 uM after 18 hrs by flow cytometric analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
4. | ALA2352791 | B | Inhibition of PCNA in human GM14931 cells expressing truncated X-PG transfected with aqueous acid-treated pGL4 assessed as inhibition of translation DNA synthesis-mediated repair of cisplatin-damaged plasmid at 10 uM after 72 hrs by luciferase reporter assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA2352792 | B | Inhibition of PCNA in human HeLa cells expressing X-PG assessed as inhibition of translation DNA synthesis-mediated repair of cisplatin-damaged plasmid at 10 uM after 72 hrs by luciferase reporter assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
6. | ALA2352794 | B | Inhibition of PCNA in human GM14931 cells expressing truncated X-PG assessed as inhibition of translation DNA synthesis-mediated repair of cisplatin-damaged plasmid at 10 uM after 72 hrs by luciferase reporter assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
7. | ALA2352795 | B | Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarization assay | Homo sapiens | 31 | single protein format | Scientific Literature | ||
8. | ALA3854648 | B | Binding affinity to full length human PCNA expressed in Escherichia coli BL21(DE3) assessed as inhibition of interaction with N-terminal 5-carboxyfluorescein-labeled PIP-box sequence peptide after 30 mins by fluorescence polarization assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
9. | ALA3854649 | B | Binding affinity to monoubiquitinated PCNA derived from human GM04312 cells assessed as inhibition of interaction with His8-tagged DNA polymerase eta (551 to 713 residues) after 3 hrs by pull down assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
10. | ALA4612067 | B | Inhibition of PCNA-mediated cell cycle progression in human BPH-1 cells assessed as reduction in cdk4 level at 125 to 500 uM after 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4612068 | B | Inhibition of PCNA-mediated cell cycle progression in human BPH-1 cells assessed as reduction in cyclin D level at 250 to 500 uM after 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |