| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1218226 | B | Inhibition of JAK-mediated interferon-gamma/anisomycin-induced Stat1 phosphorylation in human U937 cells by Phospho-Flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA1218229 | B | Inhibition of JAK-mediated GM-CSF-induced Stat5 phosphorylation in human U937 cells by Phospho-Flow cytometry at 20 uM | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA1218230 | B | Inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation in human U937 cells by Phospho-Flow cytometry at 20 uM | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA5253280 | B | Inhibition of JAK (unknown origin) | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 5. | ALA3225233 | B | Inhibition of JAK-mediated STAT5 phosphorylation in HEL cells by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4003456 | B | Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/ mouse anti-human CD3 stimulated STAT5 phosphorylation at tyrosine residue preincubated for 1 hr followed by IL2/CD3 stimulation after 30 mins by immunofluorescence assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA4003459 | B | Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/mouse anti-human CD3 stimulated IFNgamma production preincubated for 1 hr followed by IL2/CD3 stimulation measured after 18 hrs by by ELISA | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 8. | ALA4003461 | B | Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/ mouse anti-human CD3 stimulated STAT5 phosphorylation at tyrosine residue by measuring time taken for inhibition to reverse by 50% at 10-fold IC50 preincubated with cells followed by compound washout and subsequent IL2/CD3 stimulation by immunofluorescence assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 9. | ALA4003504 | B | Inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/ mouse anti-human CD3 stimulated STAT5 phosphorylation at tyrosine residue at 10-fold IC50 preincubated for 1 hr followed by compound washout and subsequent IL2/CD3 stimulation measured after 30 mins by immunofluorescence assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA4003505 | B | Time-dependent inhibition of JAK in human PBMC assessed as reduction in human recombinant IL-2/ mouse anti-human CD3 stimulated STAT5 phosphorylation at tyrosine residue at 10-fold IC50 preincubated with cells followed by compound washout and subsequent IL2/CD3 stimulation by immunofluorescence assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4026122 | B | Inhibition of JAK signaling pathway in human MDA-MB-468 cells assessed as reduction in Il-6 induced STAT3 phosphorylation at 10 uM preincubated for 30 mins followed by IL-6 induction measured after 30 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4152877 | B | Inhibition of JAK (unknown origin) | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 13. | ALA4220986 | B | Inhibition of JAK phosphorylation (unknown origin) | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 14. | ALA4313546 | B | Binding affinity to JAK in human PBMC assessed as half life measured after compound washout was out | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 15. | ALA4347591 | B | Activation of JAK in human MDA-MB-231 cells assessed as upregulation of p-STAT3-Tyr705 level at 5 uM after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4347616 | B | Inhibition of JAK in human MDA-MB-231 cells assessed as decrease in p-STAT3-Tyr705 level at 5 to 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4347619 | B | Inhibition of JAK in human MDA-MB-231 cells assessed as decrease in upregulation of p-STAT3-Tyr705 level at 5 uM after 12 hrs in presence of ruxolitinib by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4478767 | B | Inhibition of JAK in human B lymphocyte cells assessed as suppression of IL4-induced STAT6 phosphorylation preincubated for 1 hr followed by IL4 addition measured after 41/2 to 5 hrs by STAT6 reporter gene assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 19. | ALA4666933 | B | Inhibition of JAK in human BEAS-2B cells assessed as reduction in IL13-induced STAT6 phosphorylation incubated for 1 hr followed by IL13 addition and measured after 15 mins by immunofluorescence assay | Homo sapiens | 57 | cell-based format | Scientific Literature | ||
| 20. | ALA4666934 | B | Inhibition of JAK in human BEAS-2B cells assessed as reduction in IL13-induced STAT6 phosphorylation at 1 uM incubated for 1 hr followed by IL13 addition and measured after 15 mins by immunofluorescence assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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