| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3294871 | B | Binding affinity to His6-tagged PDE-delta (unknown origin) measured every 3 mins by fluorescence polarization assay | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 2. | ALA3294872 | B | Binding affinity to PDE-delta (unknown origin) assessed as shift in melting temperature | Homo sapiens | 16 | single protein format | Scientific Literature | ||
| 3. | ALA3294873 | B | Binding affinity to PDE-delta (unknown origin) by time-resolved fluorescence anisotropic analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 4. | ALA3292772 | B | Binding affinity to PDE-delta (unknown origin) by SPR analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 5. | ALA3292774 | B | Binding affinity to PDE-delta in human PancTuI cells assessed as inhibition of Ras-PDE-delta complex formation after 2 hrs by pull down assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3292775 | B | Binding affinity to PDE-delta in human PancTuI cells assessed as inhibition of Ras-PDE-delta complex formation at 500 nM after 2 hrs by pull down assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4031112 | B | Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 8. | ALA4031120 | B | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced AKT phosphorylation at Ser473 at 25 uM after 1 hr by Western blot method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4031121 | B | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced ERK phosphorylation at Thr202/Thr204 at 25 uM after 1 hr by Western blot method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4031122 | B | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced AKT phosphorylation at Ser473 at 10 uM incubated for >5 hrs by Western blot method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4031123 | B | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as downregulation of EGF-induced ERK phosphorylation at Thr202/Thr204 at 10 uM incubated for >5 hrs by Western blot method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4031125 | B | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as increase in endogenous RAS distribution to endomembranes at 25 uM incubated for 2 hrs by immunofluorescence staining based method | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 13. | ALA4031126 | B | Inhibition of PDEdelta in KRAS-dependent human Capan1 cells assessed as increase in endogenous RAS distribution to endomembranes at 10 uM incubated for 2 hrs by immunofluorescence staining based method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4031129 | B | Binding affinity to PDEdelta (unknown origin) assessed as change in melting temperature at 1 mM by circular dichroism spectroscopy | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA4031130 | B | Reversible inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) at Kd incubated for 10 hrs by fluorescence anisotropy assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 16. | ALA4038107 | B | Inhibition of atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 17. | ALA4038109 | B | Inhibition of KRAS-PDEdelta interaction in unstimulated KRAS-dependent human Capan1 cells assessed as downregulation of unstimulated AKT phosphorylation at S473 at 10 uM after 1 hr by Western blot analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 18. | ALA4038110 | B | Inhibition of KRAS-PDEdelta interaction in unstimulated KRAS-dependent human Capan1 cells assessed as downregulation of ERK phosphorylation at Thr202/Tyr204 at 10 uM after 1 hr by Western blot analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 19. | ALA4038111 | B | Inhibition of KRAS-PDEdelta interaction in unstimulated KRAS-dependent human Capan1 cells assessed as downregulation of AKT phosphorylation at Ser473 at 20 uM after 1 hr by Western blot analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 20. | ALA4038112 | B | Inhibition of KRAS-PDEdelta interaction in unstimulated KRAS-dependent human Capan1 cells assessed as downregulation of ERK phosphorylation at Thr202/Tyr204 at 20 uM after 1 hr by Western blot analysis | Homo sapiens | 2 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!