| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4147117 | B | Binding affinity to recombinant human sRANKL expressed in Escherichia coli by SPR assay | Homo sapiens | 3 | ALA4145488 | assay format | Scientific Literature | |
| 2. | ALA4147118 | B | Binding affinity to recombinant human sRANKL expressed in Escherichia coli assessed as association constant by SPR assay | Homo sapiens | 3 | ALA4145488 | assay format | Scientific Literature | |
| 3. | ALA4147119 | B | Binding affinity to recombinant human sRANKL expressed in Escherichia coli assessed as dissociation constant by SPR assay | Homo sapiens | 3 | ALA4145488 | assay format | Scientific Literature | |
| 4. | ALA4397821 | B | Binding affinity to human RANKL by surface plasmon resonance analysis | Homo sapiens | 7 | ALA4396880 | single protein format | Scientific Literature | |
| 5. | ALA4397822 | B | Inhibition of RANK binding to human RANKL measured after 1 h by surface plasmon resonance analysis | Homo sapiens | 1 | ALA4396880 | single protein format | Scientific Literature | |
| 6. | ALA4397834 | B | Binding affinity to human RANKL measured after 1 hr by fluorescence assay | Homo sapiens | 3 | ALA4396880 | single protein format | Scientific Literature | |
| 7. | ALA4671286 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression at 2 to 10 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis | Homo sapiens | 1 | ALA4665827 | cell-based format | Scientific Literature | |
| 8. | ALA4671287 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression at 2 to 10 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis | Homo sapiens | 1 | ALA4665827 | cell-based format | Scientific Literature | |
| 9. | ALA4671288 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression by measuring cFOS protein expression at 10 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | ALA4665827 | cell-based format | Scientific Literature | |
| 10. | ALA4671289 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression by measuring cFOS protein expression at 5 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | ALA4665827 | cell-based format | Scientific Literature | |
| 11. | ALA4671290 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated cFOS expression by measuring cFOS protein expression at 2 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | ALA4665827 | cell-based format | Scientific Literature | |
| 12. | ALA4671291 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression by measuring NFATc1 protein expression at 10 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | ALA4665827 | cell-based format | Scientific Literature | |
| 13. | ALA4671292 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression by measuring NFATc1 protein expression at 5 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | ALA4665827 | cell-based format | Scientific Literature | |
| 14. | ALA4671293 | B | Inhibition of RANKL (unknown origin) in RANKL cultured mouse RAW264.7 cells assessed as reduction in RANKL/RANK-interaction mediated NFATc1 expression by measuring NFATc1 protein expression at 2 uM preincubated for 1 hr followed by cell culture addition and measured after 2 days by Western blot analysis relative to positive control (Rvb = 1 No_unit) | Homo sapiens | 2 | ALA4665827 | cell-based format | Scientific Literature | |
| 15. | ALA4671294 | B | Inhibition of human soluble RANKL trimerization assessed as increase in RANKL monomer level at 1:3 ratio of DSS to RANKL preincubated for 1 hr followed by DSS addition and measured after 1 hr by SDS-PAGE analysis | Homo sapiens | 1 | ALA4665827 | single protein format | Scientific Literature | |
| 16. | ALA4671295 | B | Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in phalloidin-labeled actin ring formation preincubated with RANKL for 1 hr followed by cell addition and subsequent media replenishment every 48 hrs for 4 days by Alexa Fluor 488-conjugated phalloidin/DAPI-staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA4665827 | cell-based format | Scientific Literature | |
| 17. | ALA4671297 | B | Inhibition of human soluble RANKL trimerization assessed as increase in RANKL monomer level preincubated for 1 hr followed by DSS addition and measured after 1 hr by SDS-PAGE analysis | Homo sapiens | 1 | ALA4665827 | single protein format | Scientific Literature | |
| 18. | ALA4671298 | B | Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in phalloidin-labeled actin ring formation at 5 to 10 uM preincubated with RANKL for 1 hr followed by cell addition and subsequent media replenishment every 48 hrs for 4 days by Alexa Fluor 488-conjugated phalloidin/DAPI-staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA4665827 | cell-based format | Scientific Literature | |
| 19. | ALA4671299 | B | Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in RANKL/M-CSF-induced TRAP activity at 5 to 10 uM preincubated with RANKL for 1 hr followed by cell addition and subsequent media replenishment every 48 hrs for 4 days | Homo sapiens | 1 | ALA4665827 | cell-based format | Scientific Literature | |
| 20. | ALA4671301 | B | Inhibition of human RANKL-induced osteoclastogenesis in RANKL cultured mouse bone marrow cells assessed as reduction in RANKL/M-CSF-induced TRAP activity at 5 uM preincubated with RANKL for 1 hr followed by cell addition and subsequent media replenishment every 48 hrs for 4 days | Homo sapiens | 37 | ALA4665827 | cell-based format | Scientific Literature |
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