| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3541089 | ADME | Competitive inhibition of CYP3A in human liver microsomes | Homo sapiens | 1 | ALA3526092 | assay format | Scientific Literature | |
| 2. | ALA3532540 | ADME | Time dependent inhibition of human CYP3A midazolam 1'-hydroxylase activity assessed as decrease in enzyme activity at 1 uM preincubated for 30 mins by IC25-shift assay | Homo sapiens | 1 | ALA3526089 | assay format | Scientific Literature | |
| 3. | ALA3532541 | ADME | Time dependent inhibition of human CYP3A testosterone 6beta-hydroxylase activity assessed as decrease in enzyme activity at 5 uM preincubated for 30 mins by IC25-shift assay | Homo sapiens | 1 | ALA3526089 | assay format | Scientific Literature | |
| 4. | ALA3531037 | ADME | Inhibition of CYP3A-mediated 1'-OH midazolam formation in human liver microsomes after 7.5 mins by LC-MS method | Homo sapiens | 2 | ALA3526092 | assay format | Scientific Literature | |
| 5. | ALA3531038 | ADME | Inhibition of CYP3A-mediated 1'-OH midazolam formation in human liver microsomes preincubated for 15 mins before substrate addition by LC-MS method | Homo sapiens | 2 | ALA3526092 | assay format | Scientific Literature | |
| 6. | ALA3531040 | ADME | Reversible competitive inhibition of CYP3A-mediated 1'-OH midazolam formation in human liver microsomes after 7.5 mins by nonlinear regression study | Homo sapiens | 2 | ALA3526092 | assay format | Scientific Literature | |
| 7. | ALA3536619 | ADME | Drug metabolism in pooled human hepatocytes assessed as disapperance rate at 1 uM by LC-MS/MS analysis in presence of 10 uM CYP3A inhibitor ketoconazole | Homo sapiens | 1 | ALA3526139 | cell-based format | Scientific Literature | |
| 8. | ALA3532647 | ADME | Reversible inhibition of human CYP3A felodipine oxidase activity | Homo sapiens | 1 | ALA3526089 | assay format | Scientific Literature | |
| 9. | ALA3532648 | ADME | Reversible inhibition of human CYP3A midazolam 1'-hydroxylase activity | Homo sapiens | 1 | ALA3526089 | assay format | Scientific Literature | |
| 10. | ALA3532649 | ADME | Reversible inhibition of human CYP3A testosterone 6beta-hydroxylase activity | Homo sapiens | 1 | ALA3526089 | assay format | Scientific Literature | |
| 11. | ALA3534783 | ADME | Decrease in CYP3A activity in rifampin-treated human hepatocytes assessed as 6-betahydroxytestosterone formation using testosterone as substrate at 2.5 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526139 | cell-based format | Scientific Literature | |
| 12. | ALA3532321 | ADME | Inhibition of CYP3A in human liver microsomes assessed as substrate metabolite formation using midazolam as substrate preincubated with microsomes for 30 mins prior to substrate addition measured after 5 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 13. | ALA3532322 | ADME | Inhibition of CYP3A in human liver microsomes assessed as substrate metabolite formation using testosterone as substrate preincubated with microsomes for 30 mins prior to substrate addition measured after 5 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 14. | ALA3532323 | ADME | Time-dependent inhibition of CYP3A in human liver microsomes assessed as testosterone 6-hydroxylation using testosterone as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 15. | ALA3535256 | ADME | Time-dependent inhibition of CYP3A in human liver microsomes assessed as testosterone 6-hydroxylation using testosterone as substrate measured after 25-fold diution by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 16. | ALA3535257 | ADME | Time-dependent inhibition of CYP3A in human liver microsomes assessed as midazolam 1'-hydroxylation using midazolam as substrate by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 17. | ALA3535258 | ADME | Time-dependent inhibition of CYP3A in human liver microsomes assessed as midazolam 1'-hydroxylation using midazolam as substrate measured after 25-fold diution by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 18. | ALA3535259 | ADME | Time-dependent inhibition of CYP3A in human liver microsomes assessed as testosterone 6-hydroxylation using testosterone as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 19. | ALA3535260 | ADME | Time-dependent inhibition of CYP3A in human liver microsomes assessed as midazolam 1'-hydroxylation using midazolam as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA3526139 | assay format | Scientific Literature | |
| 20. | ALA3535261 | ADME | Inhibition of CYP3A in human liver microsomes treated with carfilzomib up to 30 uM by LC-MS/MS analysis | Homo sapiens | 2 | ALA3526139 | assay format | Scientific Literature |
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