| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3223124 | B | Inhibition of erythrocyte 20S proteasome (unknown origin) assessed as inhibition of chymotrypsin activity after 15 mins using Suc-LLVY-AMC substrate by fluorescence assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 2. | ALA3223125 | B | Inhibition of erythrocyte 20S proteasome (unknown origin) assessed as inhibition of chymotrypsin activity at 50 uM after 15 mins using Suc-LLVY-AMC substrate by fluorescence assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 3. | ALA3223126 | B | Inhibition of erythrocyte 20S proteasome (unknown origin) assessed as inhibition of chymotrypsin activity at 10 uM after 15 mins using Suc-LLVY-AMC substrate by fluorescence assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 4. | ALA3223127 | B | Inhibition of 20S proteasome in human MelJuSo UbG76V-YFP cells assessed as accumulation of K48-linked poly-ubiquitinated proteins at 0.1 uM after 6 hrs by immunoblot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3223128 | B | Inhibition of 20S proteasome in human MelJuSo UbG76V-YFP cells assessed as accumulation of UbG76V-YFP protein at 0.1 uM after 6 hrs by immunoblot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3222879 | B | Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 90 mins by fluorescence assay | Homo sapiens | 3 | protein complex format | Scientific Literature | ||
| 7. | ALA3222883 | B | Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate assessed as decrease in enzyme velocity | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 8. | ALA3222884 | B | Inhibition of 20S proteasome in human HeLa cells expressing GFP-tagged ubiquitin G76V mutant at 23 uM after 16 hrs by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA3222885 | B | Inhibition of 20S proteasome in human HeLa cells expressing GFP-tagged ubiquitin G76V mutant at 26 nM after 16 hrs by fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3240083 | B | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate | Homo sapiens | 17 | protein complex format | Scientific Literature | ||
| 11. | ALA3240084 | B | Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrate | Homo sapiens | 13 | protein complex format | Scientific Literature | ||
| 12. | ALA3240085 | B | Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrate | Homo sapiens | 13 | protein complex format | Scientific Literature | ||
| 13. | ALA3242187 | B | Reversible inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate measured after drug wash-out | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 14. | ALA3242188 | B | Irreversible inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate measured after drug wash-out | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 15. | ALA3266056 | B | Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate at 1 ug/ml by fluorescence method | Homo sapiens | 33 | protein complex format | Scientific Literature | ||
| 16. | ALA3266057 | B | Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method | Homo sapiens | 35 | protein complex format | Scientific Literature | ||
| 17. | ALA3266564 | B | Inhibition of chymotrypsin-like activity of 26S proteasome in intact human Karpas 1106p cells assessed as substrate hydrolysis using Suc-LLVY-(D)-aminoluciferin as substrate after 3 hrs by cell-based Proteasome-Glo assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA3295791 | B | Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 5 | protein complex format | Scientific Literature | ||
| 19. | ALA4334249 | B | Inhibition of human 26S proteasome using suc-LLVY-AMC as substrate up to 40 mins by fluorescence assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 20. | ALA4370612 | B | Inhibition of 26S proteosome in human Hep3B cells grown under in hypoxic condition for 4 hrs assessed as downregulation of HIF1alpha level at 10 uM added together with cycloheximide and measured after up 45 mins post dose by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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