Antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 2.5 mg/kg, po administered once daily after 19 consecutive days relative to control
Antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 5 mg/kg, po administered once daily after 19 consecutive days relative to control
Antitumor activity against human NCI-H209 cells xenografted in po dosed BALB/c nude mouse assessed as tumor growth inhibition administered once daily after 19 consecutive days
Potentiation of TMZ-induced antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as tumor relapse rate at 0.75 mg/kg, po BID for 28 days and co-treated with 50 mg/kg, po QD TMZ for 5 consecutive days at start of study and again 14 days later and measured after 68 days
Antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as tumor relapse at 50 mg/kg, po QD for 5 consecutive days at start of study and again 14 days later and measured after 48 days
Antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as PR rate at 50 mg/kg, po QD for 5 consecutive days at start of study and again 14 days later
Potentiation of TMZ-induced antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as PR rate at 0.75 mg/kg, po BID for 28 days and co-treated with 50 mg/kg, po QD TMZ for 5 consecutive days at start of study and again 14 days later
Potentiation of TMZ-induced antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as inhibition of tumor growth at 0.75 mg/kg, po BID for 28 days and co-treated with 50 mg/kg, po QD TMZ for 5 consecutive days at start of study and again 14 days later
Antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as inhibition of tumor growth at 12 mg/kg, po BID for 28 days
Antitumor activity against human NCI-H209 cells xenografted in BALB/c nude mouse assessed as inhibition of tumor growth at 50 mg/kg, po QD for 5 consecutive days at start of study and again 14 days later