# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA752767 | Binding | Binding affinity towards NPFF receptor was measured by the displacement of [125I]-YLFQPQRF-NH2 | 3 | ALA1134477 | single protein format | Scientific Literature | ||
2. | ALA755904 | Binding | Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF | 20 | ALA1127731 | cell membrane format | Scientific Literature | ||
3. | ALA2187510 | ADME | Activation of NPFF2R in Sprague-Dawley rat cardiomyocytes assessed inhibition of cardiac function by measuring decrease in peak shortening amplitude at 10 nM incubated for 20 mins | Rattus norvegicus | 1 | ALA2177060 | cell-based format | Scientific Literature | |
4. | ALA2187511 | ADME | Activation of NPFF2R in Sprague-Dawley rat cardiomyocytes assessed as inhibition of cardiac function by measuring decrease in return velocity at 10 nM incubated for 20 mins | Rattus norvegicus | 1 | ALA2177060 | cell-based format | Scientific Literature | |
5. | ALA2187512 | ADME | Activation of NPFF2R in Sprague-Dawley rat cardiomyocytes assessed inhibition of cardiac function by measuring decrease in departure velocity at 10 nM incubated for 20 mins | Rattus norvegicus | 1 | ALA2177060 | cell-based format | Scientific Literature | |
6. | ALA2187513 | Binding | Activation of NPFF2R in Sprague-Dawley rat cardiac myocytes assessed as effect on cardiac function at 10 nM incubated for 20 mins | Rattus norvegicus | 1 | ALA2177060 | cell-based format | Scientific Literature | |
7. | ALA2187514 | Functional | Antagonist activity at NPFF2R in Sprague-Dawley rat cardiac myocytes assessed as attenuation of human RFRP-1-induced reduction in cardiac function at 10 nM incubated for 20 mins | Rattus norvegicus | 1 | ALA2177060 | cell-based format | Scientific Literature | |
8. | ALA2187519 | Functional | Antagonist activity at NPFF2R in Sprague-Dawley rat ventricular cardiac myocytes assessed as attenuation of human RFRP1-induced reduction in cardiac contractility at 10 nM incubated for 20 mins | Rattus norvegicus | 1 | ALA2177060 | assay format | Scientific Literature | |
9. | ALA2187520 | ADME | Antagonist activity at NPFF2R in Sprague-Dawley rat ventricular cardiac myocytes assessed as modulation in cardiac contractility at 10 nM incubated for 20 mins relative to human RFRP-1 | Rattus norvegicus | 1 | ALA2177060 | assay format | Scientific Literature | |
10. | ALA2187521 | ADME | Activation of NPFF2R in Sprague-Dawley rat cardiomyocytes assessed as inhibition of cardiac function by measuring decrease in return velocity at 10 nM incubated for 20 mins relative to human RFRP-1 | Rattus norvegicus | 22 | ALA2177060 | cell-based format | Scientific Literature | |
11. | ALA2187522 | ADME | Activation of NPFF2R in Sprague-Dawley rat cardiomyocytes assessed inhibition of cardiac function by measuring decrease in departure velocity at 10 nM incubated for 20 mins relative to human RFRP-1 | Rattus norvegicus | 22 | ALA2177060 | cell-based format | Scientific Literature | |
12. | ALA2187523 | ADME | Activation of NPFF2R in Sprague-Dawley rat cardiomyocytes assessed inhibition of cardiac function by measuring decrease in peak shortening amplitude at 10 nM incubated for 20 mins relative to human RFRP-1 | Rattus norvegicus | 22 | ALA2177060 | cell-based format | Scientific Literature | |
13. | ALA4772218 | Binding | Displacement of [125I]-1DMeNPFF from rat NPFFR2 expressed in HEK293 cells incubated for 2 hrs by scintillation counting method | Rattus norvegicus | 2 | ALA4765381 | cell-based format | Scientific Literature | |
14. | ALA4772263 | Binding | Binding affinity to rat NPFFR2 by radioligand binding assay | Rattus norvegicus | 2 | ALA4765381 | single protein format | Scientific Literature | |
15. | ALA4772265 | Binding | Agonist activity at rat NPFFR2 | Rattus norvegicus | 1 | ALA4765381 | single protein format | Scientific Literature | |
16. | ALA4772266 | Binding | Agonist activity at rat NPFFR2 by cell-based assay relative to control | Rattus norvegicus | 1 | ALA4765381 | cell-based format | Scientific Literature |