| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA748275 | B | Compound was evaluated for the affinity at the cloned radio labelled Muscarinic acetylcholine receptor M5 | 4 | single protein format | Scientific Literature | |||
| 2. | ALA743995 | B | Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]quinuclidinyl benzilate (0.8 nM) in vitro to membranes of rat brain without cerebellum | 20 | cell membrane format | Scientific Literature | |||
| 3. | ALA915255 | B | Displacement of radiolabeled atropine from rat brain muscarinic M5 receptor at 10 uM | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 4. | ALA930977 | F | Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay | Rattus norvegicus | 11 | cell-based format | Scientific Literature | ||
| 5. | ALA932109 | B | Displacement of [3H]NMS from rat muscarinic M5 receptor expressed in CHO cells | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA1919029 | F | Agonist activity at rat muscarinic M5 receptor expressed in CHO cells | Rattus norvegicus | 13 | cell-based format | Scientific Literature | ||
| 7. | ALA1919232 | F | Agonist activity at rat recombinant muscarinic M5 receptor by HTS cell based assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA1218678 | F | Allosteric activation of rat recombinant muscarinic M5 receptor expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization at 10 uM after 1 hr by fluorescence assay | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA1218685 | F | Agonist activity at rat recombinant muscarinic M5 receptor expressed in CHO cells assessed as induction of calcium mobilization at 10 uM after 1 hr by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA1218686 | F | Antagonist activity at rat recombinant muscarinic M5 receptor expressed in CHO cells assessed as calcium mobilization at 10 uM after 1 hr by fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA1218692 | B | Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA2320107 | B | Positive allosteric modulation of rat muscarinic M5 receptor assessed as acetylcholine response | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 13. | ALA2320123 | B | Orthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 100 uM oxotremorine-evoked [3H]DA release at 1 uM | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 14. | ALA2320124 | B | Orthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 10 uM oxotremorine-evoked [3H]DA release | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 15. | ALA2320125 | B | Orthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 100 uM oxotremorine-evoked [3H]DA release | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 16. | ALA2319089 | F | Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA2384199 | B | Positive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced response | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 18. | ALA2384201 | B | Positive allosteric modulation of rat muscarinic M5 receptor | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 19. | ALA2384203 | B | Positive allosteric modulation of rat muscarinic M5 receptor relative to acetylcholine | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
| 20. | ALA3107813 | F | Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay | Rattus norvegicus | 4 | cell-based format | Scientific Literature |
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