| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3242423 | B | Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as receptor internalization at 100 uM after 20 mins by confocal microscopic analysis | Rattus norvegicus | 10 | cell-based format | Scientific Literature | ||
| 2. | ALA3242424 | B | Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as receptor internalization at 100 nM after 20 mins by confocal microscopic analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3242427 | B | Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as total receptor internalization at 10 to 100 uM after 20 mins by confocal microscopic analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3242428 | B | Antagonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of apelin-17-induced receptor internalization at 100 uM after 20 mins by confocal microscopic analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3242431 | F | Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of forskolin-induced cAMP production after 30 mins by fluorescence analysis | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA3242432 | F | Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of forskolin-induced cAMP production after 30 mins by fluorescence analysis relative to control | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA4040233 | B | Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma counting | Rattus norvegicus | 16 | cell-based format | Scientific Literature | ||
| 8. | ALA4324420 | F | Agonist activity at rat APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by HTRF assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4401047 | B | Displacement of [125I]-(Glp1,Nle11,Try14)apelin-13 from recombinant rat EGFP-fused apelin receptor expressed in CHO cell membrane measured after 3 hrs | Rattus norvegicus | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA4627575 | B | Displacement of [125I]-pE13F from rat EGFP-tagged APJ receptor stably expressed in CHO cell membrane measured after 1 hr | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4670161 | F | Agonist activity at rat APJ receptor stably expressed in CHO cell membranes in presence of [35S]GTPgammaS by scintillation proximity assay | Rattus norvegicus | 23 | cell-based format | Scientific Literature | ||
| 12. | ALA4670166 | F | Agonist activity at rat APJ receptor stably expressed in CHO cell membranes assessed as efficacy in presence of [35S]GTPgammaS by scintillation proximity assay | Rattus norvegicus | 22 | cell-based format | Scientific Literature | ||
| 13. | ALA4703004 | B | Displacement of [125I]-pyr-1-apelin-13 from EGFP-tagged wild-type rat apelin receptor expressed in CHO cell membranes by gamma counting method | Rattus norvegicus | 25 | cell membrane format | Scientific Literature | ||
| 14. | ALA4712438 | F | Agonist activity at APJ receptor in rat NRK-52E cells assessed as effect on cAMP accumulation incubated for 1 hr by cAMP-Glo assay | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4810842 | F | Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay | Rattus norvegicus | 21 | assay format | Scientific Literature | ||
| 16. | ALA4821004 | F | Agonist activity at rat APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 hr by TR-FRET assay | Rattus norvegicus | 15 | cell-based format | Scientific Literature | ||
| 17. | ALA4840248 | F | Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production incubated for 30 mins by HTRF assay | Rattus norvegicus | 18 | cell-based format | Scientific Literature | ||
| 18. | ALA5233309 | B | Displacement of [125I]-pyr-1-apelin-13 from EGFP tagged rat apelin receptor expressed in CHO cell membrane incubated for 3 hrs by gamma counter analysis | Rattus norvegicus | 13 | cell membrane format | Scientific Literature |
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